ELIZA

return kwic search for through out of >500 occurrences
437431 occurrences (No.38 in the rank) during 5 years in the PubMed. [no cache] 500 found

270) Stem cell interactions through paracrine cell signalling can regulate a range of cell responses, including metabolic activity, proliferation and differentiation.

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PMID:23135884 DOI:10.1002/term.1643

2015 Journal of tissue engineering and regenerative medicine

* Multilineage co-culture of adipose-derived stem cells for tissue engineering.

- Stem cell interactions through paracrine cell signalling can regulate a range of cell responses, including metabolic activity, proliferation and differentiation. Moving towards the development of optimized tissue-engineering strategies with adipose-derived stem cells (ASCs), the focus of this study was on developing indirect co-culture models to study the effects of mature adipocytes, chondrocytes and osteoblasts on bovine ASC multilineage differentiation. For each lineage, ASC differentiation was characterized by histology, gene expression and protein expression, in the absence of key inductive differentiation factors for the ASCs. Co-culture with each of the mature cell populations was shown to successfully induce or enhance lineage-specific differentiation of the ASCs. In general, a more homogeneous but lower-level differentiation response was observed in co-culture as compared to stimulating the bovine ASCs with inductive differentiation media. To explore the role of the Wnt canonical and non-canonical signalling pathways within the model systems, the effects of the Wnt inhibitors WIF-1 and DKK-1 on multilineage differentiation in co-culture were assessed. The data indicated that Wnt signalling may play a role in mediating ASC differentiation in co-culture with the mature cell populations.

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[frequency of next (right) word to through]

(1)113 the	(12)3 biological	(23)2 direct	(34)2 low
(2)51 a	(13)3 both	(24)2 evidence	(35)2 maternal
(3)11 an	(14)3 cortical	(25)2 focus	(36)2 paracrine
(4)10 which	(15)3 histological	(26)2 four	(37)2 promoting
(5)5 their	(16)3 infancy	(27)2 human	(38)2 rat
(6)4 activation	(17)3 interaction	(28)2 information,	(39)2 reward
(7)4 its	(18)3 simulation	(29)2 inhibition	(40)2 skin
(8)4 median	(19)2 2012	(30)2 interactions	(41)2 such
(9)4 three	(20)2 August	(31)2 international	(42)2 these
(10)4 use	(21)2 PCR-based	(32)2 intersection
(11)3 analysis	(22)2 different	(33)2 interviews

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--- WordNet output for through --- =>直通の, のために, の間じゅう, 終わって, を貫いて, の中を通って, のいたるところに, を通じて Overview of adj through The adj through has 2 senses (first 1 from tagged texts) 1. (4) done, through, through with -- (having finished or arrived at completion; "certain to make history before he's done"; "it's a done deed"; "after the treatment, the patient is through except for follow-up"; "almost through with his studies") 2. through -- ((of a route or journey etc.) continuing without requiring stops or changes; "a through street"; "a through bus"; "through traffic") Overview of adv through The adv through has 5 senses (first 3 from tagged texts) 1. (5) through -- (from beginning to end; "read this book through") 2. (2) through -- (over the whole distance; "this bus goes through to New York") 3. (1) through -- (to completion; "think this through very carefully!") 4. through -- (in diameter; "this cylinder measures 15 inches through") 5. through, through and through -- (throughout the entire extent; "got soaked through in the rain"; "I'm frozen through"; "a letter shot through with the writer's personality"; "knew him through and through"; "boards rotten through and through") --- WordNet end ---