* Development and characterization of niosomal gel for topical delivery of benzoyl peroxide.
- Benzoyl peroxide (BPO) is generally considered as first line treatment against acne. Low water solubility and formation of larger clusters and limited skin permeation upon topical application necessitates the application of high amount of drug for desired action which leads to induction of skin irritation. In the present study, we developed BPO-loaded niosomal formulation to improve its permeation through skin. The niosomes were further loaded in the carbopol gel to improve contact time. The results of the skin permeation study, skin retention study revealed that niosomes can effectively improve the drug permeation through skin. Application of niosomal gel significantly reduced the bacterial load after a treatment of four days. This reduction in bacterial load was further resulted in a significant reduction in the inflammation with minimal skin irritation compared with plain drug and the plain niosomal formulation.
=>直通の, のために, の間じゅう, 終わって, を貫いて, の中を通って, のいたるところに, を通じて
Overview of adj through
The adj through has 2 senses (first 1 from tagged texts)
1. (4) done, through, through with -- (having finished or arrived at completion; "certain to make
history before he's done"; "it's a done deed"; "after the treatment, the patient is through except
for follow-up"; "almost through with his studies")
2. through -- ((of a route or journey etc.) continuing without requiring stops or changes; "a
through street"; "a through bus"; "through traffic")
Overview of adv through
The adv through has 5 senses (first 3 from tagged texts)
1. (5) through -- (from beginning to end; "read this book through")
2. (2) through -- (over the whole distance; "this bus goes through to New York")
3. (1) through -- (to completion; "think this through very carefully!")
4. through -- (in diameter; "this cylinder measures 15 inches through")
5. through, through and through -- (throughout the entire extent; "got soaked through in the rain";
"I'm frozen through"; "a letter shot through with the writer's personality"; "knew him through and
through"; "boards rotten through and through")
--- WordNet end ---