* Vessel transformation in chronic wounds under topical negative pressure therapy: an immunohistochemical analysis.
- The underlying physiological mechanism of topical negative pressure (TNP) therapy is not yet completely understood. This prospective clinical study aims to clarify a potential influence of TNP therapy on vessel proliferation and hypoxia in chronic wounds. TNP was applied on chronic wounds of 16 patients (-125 mmHg) to prepare them for a plastic-surgical reconstruction using free or pedicled flaps. Tissue biopsies were taken from the wound edge and wound bed at different time points. All samples were stained with haematoxylin and eosin, hypoxia-induced factor-1α and endothelial cell markers (CD31 and CD34) for the immunohistological analysis of inflammation, hypoxia and vessel proliferation. Between day 5 and day 8 of treatment, a considerable increase in blood vessel density could be observed, reaching a maximum of approximately 200% in contrast to the vessel density prior to treatment. In addition, the number of hypoxic and inflammatory cells was found to be increased at particular time points. This study demonstrates a stimulating effect on vessel proliferation under TNP treatment. TNP appears to support (neo-) angiogenesis and transformation of chronic non-healing wounds in a physiological wound healing process when combined with surgical debridement. This effect underlines the positive influence of TNP in the treatment of chronic wounds as shown by various clinical reports.
=>1.時代, 季節, 歳月, 当時, 現代, 一生, 年季, 就業時間, 期間, 時刻, 時点, 機会, 拍子, 速度, 何度, 何回,
時, 時間, 回, 2.時間[速度]を測定する, 時間を決める, (装置などの)タイミングを調節する
Overview of noun time
The noun time has 10 senses (first 9 from tagged texts)
1. (219) time, clip -- (an instance or single occasion for some event; "this time he succeeded"; "he
called four times"; "he could do ten at a clip")
2. (160) time -- (a period of time considered as a resource under your control and sufficient to
accomplish something; "take time to smell the roses"; "I didn't have time to finish"; "it took more
than half my time")
3. (114) time -- (an indefinite period (usually marked by specific attributes or activities); "he
waited a long time"; "the time of year for planting"; "he was a great actor in his time")
4. (43) time -- (a suitable moment; "it is time to go")
5. (36) time -- (the continuum of experience in which events pass from the future through the
present to the past)
6. (10) time -- (a person's experience on a particular occasion; "he had a time holding back the
tears"; "they had a good time together")
7. (7) clock time, time -- (a reading of a point in time as given by a clock; "do you know what time
it is?"; "the time is 10 o'clock")
8. (5) fourth dimension, time -- (the fourth coordinate that is required (along with three spatial
dimensions) to specify a physical event)
9. (1) meter, metre, time -- (rhythm as given by division into parts of equal duration)
10. prison term, sentence, time -- (the period of time a prisoner is imprisoned; "he served a prison
term of 15 months"; "his sentence was 5 to 10 years"; "he is doing time in the county jail")
Overview of verb time
The verb time has 5 senses (first 3 from tagged texts)
1. (4) clock, time -- (measure the time or duration of an event or action or the person who performs
an action in a certain period of time; "he clocked the runners")
2. (3) time -- (assign a time for an activity or event; "The candidate carefully timed his
appearance at the disaster scene")
3. (1) time -- (set the speed, duration, or execution of; "we time the process to manufacture our
cars very precisely")
4. time -- (regulate or set the time of; "time the clock")
5. time -- (adjust so that a force is applied and an action occurs at the desired time; "The good
player times his swing so as to hit the ball squarely")
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