ELIZA

return kwic search for total out of >500 occurrences
296134 occurrences (No.80 in the rank) during 5 years in the PubMed. [cache]

241) Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P < .05) and decrease in heart mass (P < .05), ratio of the heart mass/body mass (P < .05), transverse diameters of cardiomyocytes (P < .001), concentration of serum high-sensitivity C-reactive protein (P < .001), and total cholesterol (P < .01) compared with obese nontreated rats.

--- ABSTRACT ---

PMID:24327768 DOI:10.1177/0003319713514477

2015 Angiology

* Estradiol in vivo induces changes in cardiomyocytes size in obese rats.

- We studied the in vivo effects of estradiol on size and biochemical parameters of cardiomyocytes in pathophysiological conditions such as obesity and insulin resistance. Male Wistar rats were normally fed (controls, n = 7) or fed with high-fat diet (obese, n = 14). Half of the obese rats (obese + estradiol, n = 7) were treated with a single dose of estradiol (40 μg/kg, intraperitoneally) and 24 hours after treatment all the rats were killed. Estradiol in vivo in obese rats resulted in a significant increase in protein kinase B (Akt) activation (P < .05) and decrease in heart mass (P < .05), ratio of the heart mass/body mass (P < .05), transverse diameters of cardiomyocytes (P < .001), concentration of serum high-sensitivity C-reactive protein (P < .001), and total cholesterol (P < .01) compared with obese nontreated rats. Our results suggest that estradiol in obese/IR rats affects the size of cardiomyocytes and its actions lead in vivo to a reduction in obesity-induced cardiac hypertrophy, via Akt.

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[frequency of next (right) word to total]

(1)187 of	(14)3 adhesive	(27)2 BGP	(40)2 organic
(2)21 length	(15)3 annual	(28)2 DNA,	(41)2 oxidant
(3)13 number	(16)3 delivered	(29)2 activity	(42)2 pleural
(4)7 antioxidant	(17)3 knee	(30)2 arch	(43)2 protein,
(5)7 protein	(18)3 length,	(31)2 biomass	(44)2 repetitions
(6)5 body	(19)3 optical	(32)2 collagen	(45)2 scores
(7)5 cholesterol	(20)3 or	(33)2 daily	(46)2 snack
(8)5 dose	(21)3 parenteral	(34)2 dietary	(47)2 soluble
(9)5 score	(22)3 polyphenols	(35)2 exercise	(48)2 stress
(10)4 HG	(23)3 population	(36)2 genome	(49)2 tumor
(11)4 amount	(24)3 sample	(37)2 health-care	(50)2 volume
(12)4 and	(25)3 suspended	(38)2 islet
(13)4 cell	(26)2 248	(39)2 mitochondrial

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--- WordNet output for total --- =>1.(車が)全壊する, 全損する, 2.全体の, 全ての, 総計の, 総体の, 全くの, 完全な, 総力の, 3.総額, 総計, 全体の, (車が)全壊する, 合計(する), なる Overview of noun total The noun total has 2 senses (first 2 from tagged texts) 1. (13) sum, total, totality, aggregate -- (the whole amount) 2. (6) sum, amount, total -- (a quantity obtained by the addition of a group of numbers) Overview of verb total The verb total has 3 senses (first 2 from tagged texts) 1. (16) total, number, add up, come, amount -- (add up in number or quantity; "The bills amounted to $2,000"; "The bill came to $2,000") 2. (2) total, tot, tot up, sum, sum up, summate, tote up, add, add together, tally, add up -- (determine the sum of; "Add all the people in this town to those of the neighboring town") 3. total -- (damage beyond the point of repair; "My son totaled our new car"; "the rock star totals his guitar at every concert") Overview of adj total The adj total has 2 senses (first 2 from tagged texts) 1. (31) entire, full, total -- (constituting the full quantity or extent; complete; "an entire town devastated by an earthquake"; "gave full attention"; "a total failure") 2. (2) full, total -- (complete in extent or degree and in every particular; "a full game"; "a total eclipse"; "a total disaster") --- WordNet end ---