kwic
total
total
right
off
ON
346
1
100
500
strict
ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -
return
kwic search for total out of >500 occurrences
296134 occurrences (No.80 in the rank) during 5 years in the PubMed. [cache]
--- ABSTRACT ---
--- ABSTRACT END ---
[frequency of next (right) word to total]
296134 occurrences (No.80 in the rank) during 5 years in the PubMed. [cache]
| 346) All models included age, sex, education, estimated total intracranial volume, multi-site scanner differences, and cardiovascular disease risk using Framingham criteria as covariates. |
| PMID:34262445 DOI:10.3389/fnagi.2021.672535 |
| 2021 Frontiers in aging neuroscience |
| * Frontal White Matter Hyperintensities and Executive Functioning Performance in Older Adults. |
| - Frontal lobe structures decline faster than most other brain regions in older adults. Age-related change in the frontal lobe is associated with poorer executive function (e.g., working memory, switching/set-shifting, and inhibitory control). The effects and presence of frontal lobe white matter hyperintensities (WMH) on executive function in normal aging is relatively unknown. The current study assessed relationships between region-specific frontal WMH load and cognitive performance in healthy older adults using three executive function tasks from the NIH Toolbox (NIHTB) Cognition Battery. A cohort of 279 healthy older adults ages 65-88 completed NIHTB and 3T T1-weighted and FLAIR MRI. Lesion Segmentation Toolbox quantified WMH volume and generated lesion probability maps. Individual lesion maps were registered to the Desikan-Killiany atlas in FreeSurfer 6.0 to define regions of interest (ROI). Independent linear regressions assessed relationships between executive function performance and region-specific WMH in frontal lobe ROIs. All models included age, sex, education, estimated total intracranial volume, multi-site scanner differences, and cardiovascular disease risk using Framingham criteria as covariates. Poorer set-shifting performance was associated with greater WMH load in three frontal ROIs including bilateral superior frontal (left β = -0.18, FDR-p = 0.02; right β = -0.20, FDR-p = 0.01) and right medial orbitofrontal (β = -0.17, FDR-p = 0.02). Poorer inhibitory performance associated with higher WMH load in one frontal ROI, the right superior frontal (right β = -0.21, FDR-p = 0.01). There were no significant associations between working memory and WMH in frontal ROIs. Our study demonstrates that location and pattern of frontal WMH may be important to assess when examining age-related differences in cognitive functions involving switching/set-shifting and inhibition. On the other hand, working memory performance was not related to presence of frontal WMH in this sample. These data suggest that WMH may contribute selectively to age-related declines in executive function. Findings emerged beyond predictors known to be associated with WMH presence, including age and cardiovascular disease risk. The spread of WMH within the frontal lobes may play a key role in the neuropsychological profile of cognitive aging. Further research should explore whether early intervention on modifiable vascular factors or cognitive interventions targeted for executive abilities may help mitigate the effect of frontal WMH on executive function. |
[
right
kwic]
(1)271  of |
(8)4 volume |
(15)2 WMS |
(22)2 drug-related |
| (2)9 number |
(9)3 costs |
(16)2 active |
(23)2 hemoglobin |
| (3)8 OH |
(10)3 knee |
(17)2 amount |
(24)2 intracranial |
| (4)6 energy |
(11)3 mean |
(18)2 cholesterol |
(25)2 plasma |
| (5)4 body |
(12)3 radioactivity |
(19)2 cholesterol, |
(26)2 variation |
| (6)4 protein |
(13)2 *null* | (20)2 clearance |
|
| (7)4 the |
(14)2 72 |
(21)2 data |
add keyword
--- WordNet output for total ---