ELIZA

return kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [cache]

10) The transcriptional targets of EWSFLI1 have been viewed as promising and novel drug targets in the treatment of ES.

--- ABSTRACT ---

PMID:34073779 DOI:10.3390/cells10061300

2021 Cells

* Identification of a New Transcriptional Co-Regulator of STEAP1 in Ewing's Sarcoma.

- Ewing's sarcoma (ES) is caused by a chromosomal translocation leading to the formation of the fused EWSFLI1 gene, which codes for an aberrant transcription factor EWSFLI1. The transcriptional targets of EWSFLI1 have been viewed as promising and novel drug targets in the treatment of ES. One such target is six transmembrane epithelial antigen of the prostate 1 (STEAP1), a transmembrane protein that is upregulated by EWSFLI1 in ES. STEAP1 is a hallmark of tumor invasiveness and an indicator of tumor responsiveness to therapy. EWSFLI1 binds to the STEAP1 promoter region, but the mechanism of action by which it upregulates STEAP1 expression in ES is not entirely understood. Upon analysis of the STEAP1 promoter, we predicted two binding sites for NKX2.2, another crucial transcription factor involved in ES pathogenesis. We confirmed the interaction of NKX2.2 with the STEAP1 promoter using chromatin immunoprecipitation (ChIP) analysis. We used single-molecule RNA imaging, biochemical, and genetic studies to identify the novel role of NKX2.2 in regulating STEAP1 expression in ES. Our results show that NKX2.2 is a co-regulator of STEAP1 expression and functions by interacting with the STEAP1 promoter at sites proximal to the reported EWSFLI1 sites. The co-operative interaction of NKX2.2 with EWSFLI1 in regulating STEAP1 holds potential as a new target for therapeutic interventions for ES.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to treatment]

(1)68 of	(13)7 planning	(25)3 outcome	(37)2 efficacy
(2)50 null	(14)6 to	(26)3 protocols	(38)2 goals
(3)29 and	(15)4 approaches	(27)3 that	(39)2 group
(4)23 for	(16)4 methods	(28)2 a	(40)2 groups
(5)22 with	(17)4 option	(29)2 as	(41)2 may
(6)15 options	(18)4 options,	(30)2 at	(42)2 ranks
(7)13 in	(19)4 ranking	(31)2 being	(43)2 reduced
(8)9 effect	(20)4 regimens	(32)2 compared	(44)2 resistance
(9)9 effects	(21)4 strategies	(33)2 decisions,	(45)2 screening,
(10)8 is	(22)3 adherence	(34)2 development	(46)2 through
(11)8 on	(23)3 approach	(35)2 did	(47)2 were
(12)7 outcomes	(24)3 or	(36)2 dose

add keyword

--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---