ELIZA

return kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found

113) However, the VTA number of TH-positive neurons suffered no alterations after the different treatment.

--- ABSTRACT ---

PMID:23927484 DOI:10.1111/adb.12083

2015 Addiction biology

* Morphine regulates Argonaute 2 and TH expression and activity but not miR-133b in midbrain dopaminergic neurons.

- Epigenetic changes such as microRNAs (miRs)/Ago2-induced gene silencing represent complex molecular signature that regulate cellular plasticity. Recent studies showed involvement of miRs and Ago2 in drug addiction. In this study, we show that changes in gene expression induced by morphine and morphine withdrawal occur with concomitant epigenetic modifications in the mesolimbic dopaminergic (DA) pathway [ventral tegmental area (VTA)/nucleus accumbens (NAc) shell], which is critically involved in drug-induced dependence. We found that acute or chronic morphine administration as well as morphine withdrawal did not modify miR-133b messenger RNA (mRNA) expression in the VTA, whereas Ago2 protein levels were decreased and increased in morphine-dependent rats and after morphine withdrawal, respectively. These changes were paralleled with enhanced and decreased NAc tyrosine hydroxylase (TH) protein (an early DA marker) in morphine-dependent rats and after withdrawal, respectively. We also observed changes in TH mRNA expression in the VTA that could be related to Ago2-induced translational repression of TH mRNA during morphine withdrawal. However, the VTA number of TH-positive neurons suffered no alterations after the different treatment. Acute morphine administration produced a marked increase in TH activity and DA turnover in the NAc (shell). In contrast, precipitated morphine withdrawal decreased TH activation and did not change DA turnover. These findings provide new information into the possible correlation between Ago2/miRs complex regulation and DA neurons plasticity during opiate addiction.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to treatment]

(1)101 of	(14)4 showed	(27)3 the	(40)2 leads
(2)53 null	(15)4 were	(28)3 to	(41)2 led
(3)38 with	(16)3 as	(29)3 without	(42)2 may
(4)29 for	(17)3 by	(30)2 after	(43)2 program
(5)23 and	(18)3 cycle	(31)2 also	(44)2 protocols
(6)11 in	(19)3 group	(32)2 are	(45)2 response
(7)9 was	(20)3 modalities	(33)2 can	(46)2 schizophrenia
(8)6 groups	(21)3 on	(34)2 concentration	(47)2 seems
(9)6 options	(22)3 option	(35)2 cycles	(48)2 significantly
(10)5 or	(23)3 outcomes	(36)2 effects	(49)2 strategies
(11)4 allocation	(24)3 period	(37)2 group,
(12)4 completion	(25)3 plants	(38)2 induced
(13)4 effect	(26)3 success	(39)2 is

add keyword

--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---