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677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found

130) The expression level of phospholipase A (PLA) was significantly down-regulated at both the mRNA and protein levels in male mice after combined treatment.

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PMID:23804495 DOI:10.1002/tox.21885

2015 Environmental toxicology

* The combined effects of DEHP and PCBs on phospholipase in the livers of mice.

- Di(2-ethylhexyl) phthalate (DEHP) and polychlorinated biphenyls (PCBs) are two widely distributed pollutants that are of great concern due to their adverse health effects. However, few studies have investigated the combined effects of DEHP and PCBs. In this study, adult mice were continuously exposed to mixtures of DEHP (15 mg/kg bodyweight/day) and Aroclor 1254 (7.5 mg/kg bodyweight/day) for 12 days to investigate the combined effects of these compounds. The results showed that the ratio of the liver weight to the body weight was higher in the treated group than that in the control group. The effects of combined exposure on three important receptors, the proliferator-activated receptor (PPAR), estrogen receptor (ER), and aryl hydrocarbon receptor (AHR), were investigated. The mRNA level of PPARγ was significantly up-regulated after exposure. The expression level of ERα was decreased in the male treated group. In contrast, the expression levels of AHR and related genes (cyp1a1 and cyp1b1) were not markedly affected. The expression level of phospholipase A (PLA) was significantly down-regulated at both the mRNA and protein levels in male mice after combined treatment. In all, our study demonstrated the combined effects of DEHP and PCBs on the expression levels of key receptors in mice. The combined exposure led to a decrease in phospholipase in male mice.

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(1)101 of	(14)4 showed	(27)3 the	(40)2 leads
(2)53 null	(15)4 were	(28)3 to	(41)2 led
(3)38 with	(16)3 as	(29)3 without	(42)2 may
(4)29 for	(17)3 by	(30)2 after	(43)2 program
(5)23 and	(18)3 cycle	(31)2 also	(44)2 protocols
(6)11 in	(19)3 group	(32)2 are	(45)2 response
(7)9 was	(20)3 modalities	(33)2 can	(46)2 schizophrenia
(8)6 groups	(21)3 on	(34)2 concentration	(47)2 seems
(9)6 options	(22)3 option	(35)2 cycles	(48)2 significantly
(10)5 or	(23)3 outcomes	(36)2 effects	(49)2 strategies
(11)4 allocation	(24)3 period	(37)2 group,
(12)4 completion	(25)3 plants	(38)2 induced
(13)4 effect	(26)3 success	(39)2 is

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---