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677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found

173) The present study was undertaken to determine whether subacute treatment with aqueous extract of carob (Ceratonia siliqua L.) pods (AECPs) protects against ethanol (EtOH)-induced oxidative stress in rat liver.

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PMID:23363576 DOI:10.1177/0748233713475506

2015 Toxicology and industrial health

* Hepatoprotective effect of carob against acute ethanol-induced oxidative stress in rat.

- The present study was undertaken to determine whether subacute treatment with aqueous extract of carob (Ceratonia siliqua L.) pods (AECPs) protects against ethanol (EtOH)-induced oxidative stress in rat liver. Animals were divided into four groups: control, carob, EtOH and EtOH + carob. Wistar rats were intraperitoneally pretreated with AECP (600 mg/kg body weight (bw)) during 7 days and intoxicated for 6 h by acute oral administration of EtOH (6 g/kg bw) 24 h after the last injection. We found that acute administration of EtOH leads to hepatotoxicity as monitored by the increase in the levels of hepatic marker aspartate aminotransferase and alanine aminotransferase as well as hepatic tissue injury. EtOH also increased the formation of malondialdehyde in the liver, indicating an increase in lipid peroxidation and depletion of antioxidant enzyme activities as superoxide dismutase, catalase and glutathione peroxidase. Subacute carob pretreatment prevented all the alterations induced by EtOH and returned their levels to near normal. Importantly, we showed that acute alcohol increased hepatic and plasmatic hydrogen peroxide and free iron levels. The carob pretreatment reversed EtOH effects to near control levels. These data suggest that carob could have a beneficial effect in inhibiting the oxidative damage induced by acute EtOH administration and that its mode of action may involve an opposite effect on plasma and tissue-free iron accumulation. Indeed, carob can be offered as a food additive to protect against EtOH-induced oxidative damage.

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(1)101 of	(14)4 showed	(27)3 the	(40)2 leads
(2)53 null	(15)4 were	(28)3 to	(41)2 led
(3)38 with	(16)3 as	(29)3 without	(42)2 may
(4)29 for	(17)3 by	(30)2 after	(43)2 program
(5)23 and	(18)3 cycle	(31)2 also	(44)2 protocols
(6)11 in	(19)3 group	(32)2 are	(45)2 response
(7)9 was	(20)3 modalities	(33)2 can	(46)2 schizophrenia
(8)6 groups	(21)3 on	(34)2 concentration	(47)2 seems
(9)6 options	(22)3 option	(35)2 cycles	(48)2 significantly
(10)5 or	(23)3 outcomes	(36)2 effects	(49)2 strategies
(11)4 allocation	(24)3 period	(37)2 group,
(12)4 completion	(25)3 plants	(38)2 induced
(13)4 effect	(26)3 success	(39)2 is

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---