ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found
252) Here, we evaluate the potential promise of ablative radiation treatment in the era of modern immunotherapy by presenting a patient with metastatic melanoma who remained disease free for over 3 years after an initial diagnosis of advanced metastatic melanoma with brain, subcutaneous tissue, mesenteric, pelvic, and retroperitoneal involvement.
--- ABSTRACT ---
PMID:23648438 DOI:10.1097/COC.0b013e3182940dc3
2015 American journal of clinical oncology
* Role of radiation therapy as immune activator in the era of modern immunotherapy for metastatic malignant melanoma.
- Metastatic melanoma is difficult to treat, and often portends a grim prognosis. For patients with cerebral metastases, the prognosis is even more dire. Systemic immunotherapy and targeted agents are emerging as the mainstay of treatment for metastatic melanoma. Although immunotherapy has been shown to prolong relapse-free survival and long-term control of micrometastatic disease, the response rate is suboptimal, prompting the need to optimize and improve therapy. Accumulating evidence suggests that in addition to effective locoregional control, radiation therapy (RT) may induce immune activation and expansion of T lymphocytes recognizing melanocyte-specific antigens including activated cytotoxic T lymphocytes that can potentially kill melanoma cells. In some cases, RT contributes to the clearance of metastatic disease in distant, nonirradiated regions, a bystander phenomenon called the abscopal effect. Here, we evaluate the potential promise of ablative radiation treatment in the era of modern immunotherapy by presenting a patient with metastatic melanoma who remained disease free for over 3 years after an initial diagnosis of advanced metastatic melanoma with brain, subcutaneous tissue, mesenteric, pelvic, and retroperitoneal involvement. The patient failed initial stereotactic radiosurgery, but responded to whole-brain RT in combination with interleukin-2 immunotherapy. Thus, combination RT with immunotherapy may be synergistic by promoting the release and processing of melanoma antigens that can be presented by dendritic cells. This in turn may augment the response to therapies that center on expansion and/or activation of antitumor T cells.
--- ABSTRACT END ---
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[frequency of next (right) word to treatment]
(1)101 of (14)4 showed (27)3 the (40)2 leads
(2)53 *null* (15)4 were (28)3 to (41)2 led
(3)38 with (16)3 as (29)3 without (42)2 may
(4)29 for (17)3 by (30)2 after (43)2 program
(5)23 and (18)3 cycle (31)2 also (44)2 protocols
(6)11 in (19)3 group (32)2 are (45)2 response
(7)9 was (20)3 modalities (33)2 can (46)2 schizophrenia
(8)6 groups (21)3 on (34)2 concentration (47)2 seems
(9)6 options (22)3 option (35)2 cycles (48)2 significantly
(10)5 or (23)3 outcomes (36)2 effects (49)2 strategies
(11)4 allocation (24)3 period (37)2 group,
(12)4 completion (25)3 plants (38)2 induced
(13)4 effect (26)3 success (39)2 is

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---