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return kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [no cache] 500 found

256) Treatment was administered topically, twice weekly for 6 weeks with final follow-up at 20 weeks.

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PMID:23848141 DOI:10.1111/iwj.12125

2015 International wound journal

* Treatment of chronic diabetic lower leg ulcers with activated protein C: a randomised placebo-controlled, double-blind pilot clinical trial.

- Lower leg ulcers are a serious and long-term complication in patients with diabetes and pose a major health concern because of the increasing number of patients diagnosed with diabetes each year. This study sought to evaluate the clinical benefit of topical activated protein C (APC) on chronic lower leg ulcers in patients with diabetes. Twelve patients were randomly assigned to receive either APC (N = 6) or physiological saline (placebo; N = 6) in a randomised, placebo-controlled, double-blind pilot clinical trial. Treatment was administered topically, twice weekly for 6 weeks with final follow-up at 20 weeks. Wound area was significantly reduced to 34·8 ± 16·4% of week 0 levels at 20 weeks in APC-treated wounds (p = 0·01). At 20 weeks, three APC-treated wounds had completely healed, compared to one saline-treated wound. Full-thickness wound edge skin biopsies showed reduced inflammatory cell infiltration and increased vascular proliferation following APC treatment. Patient stress scores were also significantly reduced following APC treatment (p < 0·05), demonstrating improved patient quality of life as assessed by the Cardiff Wound Impact Questionnaire. This pilot trial suggests that APC is a safe topical agent for healing chronic lower leg ulcers in patients with diabetes and provides supporting evidence for a larger clinical trial.

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(1)101 of	(14)4 showed	(27)3 the	(40)2 leads
(2)53 null	(15)4 were	(28)3 to	(41)2 led
(3)38 with	(16)3 as	(29)3 without	(42)2 may
(4)29 for	(17)3 by	(30)2 after	(43)2 program
(5)23 and	(18)3 cycle	(31)2 also	(44)2 protocols
(6)11 in	(19)3 group	(32)2 are	(45)2 response
(7)9 was	(20)3 modalities	(33)2 can	(46)2 schizophrenia
(8)6 groups	(21)3 on	(34)2 concentration	(47)2 seems
(9)6 options	(22)3 option	(35)2 cycles	(48)2 significantly
(10)5 or	(23)3 outcomes	(36)2 effects	(49)2 strategies
(11)4 allocation	(24)3 period	(37)2 group,
(12)4 completion	(25)3 plants	(38)2 induced
(13)4 effect	(26)3 success	(39)2 is

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---