* The impact of radiation therapy on the antitumor immunity: local effects and systemic consequences.
- The main antitumor efficacy of irradiation relies in its direct cytotoxic effect. Increasing evidence indicates a systemic effect of radiation though, mediated mainly by the immune system. In this review we wish to focus on the radiotherapy induced modifications of the soluble and cellular mediators of the antitumor immune response and summarize some of the mechanisms by which radiation driven local and systemic bystander effects can influence tumor immunogenicity. In different tumor types due to the intrinsic immunogenicity of the tumor cells and the immunological characteristics of the tumor microenvironment, different radiation induced immune modulatory mechanisms are predominant. Radiation most probably can only amplify or augment a pro-immunogenic phenotype and can hardly change by itself a net immune suppressing environment into an immune stimulating one. This immune modulatory potential of radiotherapy could be exploited in tumor treatment by developing combined radiotherapeutic and immunotherapeutic approaches. The last few years showed a dramatic increase in the knowledge of radiation induced out-of field and systemic effects, which foresees a rapid progress in the development and clinical application of these new, combined therapies for cancer cure.
=>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ
Overview of noun treatment
The noun treatment has 4 senses (first 4 from tagged texts)
1. (28) treatment, intervention -- (care provided to improve a situation (especially medical
procedures or applications that are intended to relieve illness or injury))
2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners";
"the treatment of water sewage"; "the right to equal treatment in the criminal justice system")
3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space
borrows from Italian architecture")
4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing
with some particular topic; "the book contains an excellent discussion of modal logic"; "his
treatment of the race question is badly biased")
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PubMed database: last updated on 2023-01-29 (c)sirasawa 2019