ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [cache]
32) The bone marrow is a frequent location of primary relapse after conventional cytotoxic drug treatment of human B-cell precursor acute lymphoblastic leukemia (BCP-ALL).
--- ABSTRACT ---
PMID:34591931 DOI:10.1371/journal.pone.0258140
2021 PloS one
* Analysis of acute lymphoblastic leukemia drug sensitivity by changes in impedance via stromal cell adherence.
- The bone marrow is a frequent location of primary relapse after conventional cytotoxic drug treatment of human B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Because stromal cells have a major role in promoting chemotherapy resistance, they should be included to more realistically model in vitro drug treatment. Here we validated a novel application of the xCELLigence system as a continuous co-culture to assess long-term effects of drug treatment on BCP-ALL cells. We found that bone marrow OP9 stromal cells adhere to the electrodes but are progressively displaced by dividing patient-derived BCP-ALL cells, resulting in reduction of impedance over time. Death of BCP-ALL cells due to drug treatment results in re-adherence of the stromal cells to the electrodes, increasing impedance. Importantly, vincristine inhibited proliferation of sensitive BCP-ALL cells in a dose-dependent manner, correlating with increased impedance. This system was able to discriminate sensitivity of two relapsed Philadelphia chromosome (Ph) positive ALLs to four different targeted kinase inhibitors. Moreover, differences in sensitivity of two CRLF2-drivenBCP-ALL cell lines to ruxolitinib were also seen. These results show that impedance can be used as a novel approach to monitor drug treatment and sensitivity of primary BCP-ALL cells in the presence of protective microenvironmental cells.
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[frequency of next (right) word to treatment]
(1)68 of (13)7 planning (25)3 outcome (37)2 efficacy
(2)50 *null* (14)6 to (26)3 protocols (38)2 goals
(3)29 and (15)4 approaches (27)3 that (39)2 group
(4)23 for (16)4 methods (28)2 a (40)2 groups
(5)22 with (17)4 option (29)2 as (41)2 may
(6)15 options (18)4 options, (30)2 at (42)2 ranks
(7)13 in (19)4 ranking (31)2 being (43)2 reduced
(8)9 effect (20)4 regimens (32)2 compared (44)2 resistance
(9)9 effects (21)4 strategies (33)2 decisions, (45)2 screening,
(10)8 is (22)3 adherence (34)2 development (46)2 through
(11)8 on (23)3 approach (35)2 did (47)2 were
(12)7 outcomes (24)3 or (36)2 dose

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---