ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for treatment out of >500 occurrences
677804 occurrences (No.8 in the rank) during 5 years in the PubMed. [cache]
348) Our results suggest that long-term PARP inhibitor treatment may prime both BRCA1 mutant and wild-type tumors for positive responses to immune checkpoint blockade, but by different underlying mechanisms.
--- ABSTRACT ---
PMID:33285109 DOI:10.1016/j.bcp.2020.114359
2021 Biochemical pharmacology
* Differential immunomodulatory effect of PARP inhibition in BRCA1 deficient and competent tumor cells.
- Poly-ADP-ribose polymerase (PARP) inhibitors are active against cells and tumors with defects in homology-directed repair as a result of synthetic lethality. PARP inhibitors (PARPi) have been suggested to act by either catalytic inhibition or by PARP localization in chromatin. In this study, we treat BRCA1 mutant cells derived from a patient with triple negative breast cancer and control cells for three weeks with veliparib, a PARPi, to determine if treatment with this drug induces increased levels of mutations and/or an inflammatory response. We show that long-term treatment with PARPi induces an inflammatory response in HCC1937 BRCA1 mutant cells. The levels of chromatin-bound PARP1 in the BRCA1 mutant cells correlate with significant upregulation of inflammatory genes and activation of the cyclic GMP-AMP synthase (cGAS)/signaling effector stimulator of interferon genes (STING pathway). In contrast, an increased mutational load is induced in BRCA1-complemented cells treated with a PARPi. Our results suggest that long-term PARP inhibitor treatment may prime both BRCA1 mutant and wild-type tumors for positive responses to immune checkpoint blockade, but by different underlying mechanisms.
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[frequency of next (right) word to treatment]
(1)68 of (13)7 planning (25)3 outcome (37)2 efficacy
(2)50 *null* (14)6 to (26)3 protocols (38)2 goals
(3)29 and (15)4 approaches (27)3 that (39)2 group
(4)23 for (16)4 methods (28)2 a (40)2 groups
(5)22 with (17)4 option (29)2 as (41)2 may
(6)15 options (18)4 options, (30)2 at (42)2 ranks
(7)13 in (19)4 ranking (31)2 being (43)2 reduced
(8)9 effect (20)4 regimens (32)2 compared (44)2 resistance
(9)9 effects (21)4 strategies (33)2 decisions, (45)2 screening,
(10)8 is (22)3 adherence (34)2 development (46)2 through
(11)8 on (23)3 approach (35)2 did (47)2 were
(12)7 outcomes (24)3 or (36)2 dose

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--- WordNet output for treatment --- =>1.取り扱い, 扱い, 治療, 待遇, 処理, 処置, 2.台本, シナリオ Overview of noun treatment The noun treatment has 4 senses (first 4 from tagged texts) 1. (28) treatment, intervention -- (care provided to improve a situation (especially medical procedures or applications that are intended to relieve illness or injury)) 2. (25) treatment, handling -- (the management of someone or something; "the handling of prisoners"; "the treatment of water sewage"; "the right to equal treatment in the criminal justice system") 3. (4) treatment -- (a manner of dealing with something artistically; "his treatment of space borrows from Italian architecture") 4. (2) discussion, treatment, discourse -- (an extended communication (often interactive) dealing with some particular topic; "the book contains an excellent discussion of modal logic"; "his treatment of the race question is badly biased") --- WordNet end ---