ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for tumor out of >500 occurrences
305909 occurrences (No.73 in the rank) during 5 years in the PubMed. [no cache] 500 found
19) In summary, our data suggest that a combination of antimitotic drugs targeting cyclin B degradation and TRAIL might prevent mitotic slippage and allow tumor cells to reach the threshold for apoptosis induction, thereby facilitating tumor suppression.
--- ABSTRACT ---
PMID:24488010 DOI:10.1038/onc.2013.601
2015 Oncogene
* Delaying mitotic exit downregulates FLIP expression and strongly sensitizes tumor cells to TRAIL.
- Many of the current antitumor therapeutic strategies are based on the perturbation of the cell cycle, especially during mitosis. Antimitotic drugs trigger mitotic checkpoint activation, mitotic arrest and eventually cell death. However, mitotic slippage represents a major mechanism of resistance to these treatments. In an attempt to circumvent the process of slippage, targeting mitotic exit has been proposed as a better strategy to kill tumor cells. In this study, we show that treatments that induce mitotic checkpoint activation and mitotic arrest downregulate FLICE-like inhibitory protein (FLIP) levels and sensitize several tumor cell lines to TRAIL (tumor necrosis factor-related apoptosis-inducing ligand)-induced apoptosis. Interestingly, we also demonstrate that in absence of mitotic checkpoint activation, mitotic arrest induced either by Cdc20 knockdown or overexpression of nondegradable cyclin B is sufficient to induce both FLIP downregulation and sensitivity to TRAIL. In summary, our data suggest that a combination of antimitotic drugs targeting cyclin B degradation and TRAIL might prevent mitotic slippage and allow tumor cells to reach the threshold for apoptosis induction, thereby facilitating tumor suppression.
--- ABSTRACT END ---
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[frequency of next (right) word to tumor]
(1)36 cells (17)6 size (33)3 lysis (49)2 progression,
(2)23 suppressor (18)6 suppression (34)3 onset (50)2 recurred
(3)22 progression (19)6 tissue (35)3 targeting (51)2 recurrence
(4)20 necrosis (20)6 with (36)3 to (52)2 regression
(5)19 *null* (21)5 angiogenesis (37)3 types (53)2 response
(6)17 growth (22)5 initiating (38)2 1 (54)2 samples,
(7)15 cell (23)5 suppressive (39)2 activity (55)2 site
(8)14 was (24)5 volume (40)2 burden (56)2 size,
(9)12 and (25)4 model (41)2 classification (57)2 that
(10)11 development (26)4 sites (42)2 composed (58)2 the
(11)11 in (27)4 suppressors (43)2 expression (59)2 tissue,
(12)11 of (28)3 effects (44)2 heterogeneity (60)2 tissues
(13)7 microenvironment (29)3 excision (45)2 invasion (61)2 treatment
(14)6 formation (30)3 extension (46)2 is
(15)6 promotion (31)3 had (47)2 metastasis
(16)6 samples (32)3 local (48)2 mice

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--- WordNet output for tumor --- =>膨らみ, 出っ張り, 腫瘍 Overview of noun tumor The noun tumor has 1 sense (first 1 from tagged texts) 1. (18) tumor, tumour, neoplasm -- (an abnormal new mass of tissue that serves no purpose) --- WordNet end ---