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305909 occurrences (No.73 in the rank) during 5 years in the PubMed. [no cache]
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20) Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this distinct microenvironment by shifting energy production from mitochondria towards glycolysis.
* Hypoxia and hypoxia inducible factors in tumor metabolism.
- Because of the abnormal vasculature, most growing solid tumors contain regions that experience either acute or chronic hypoxia. However, tumor cells can maintain a high glycolytic rate even when there is enough oxygen supply. Hypoxia-inducible factors (HIFs) play crucial role in the response of tumor cells to this distinct microenvironment by shifting energy production from mitochondria towards glycolysis. In this review, we focus on the metabolism of tumor cell survival in hypoxic microenvironments. Furthermore, we also emphasize the mechanisms by which hypoxia and HIFs regulate tumor metabolism.
=>膨らみ, 出っ張り, 腫瘍
Overview of noun tumor
The noun tumor has 1 sense (first 1 from tagged texts)
1. (18) tumor, tumour, neoplasm -- (an abnormal new mass of tissue that serves no purpose)
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