132) Following exercise, BG declined under both conditions but was less under INT (INT -1.1 ± 1.4 vs CON -5.3 ± 0.4 mmol/L, P = 0.037), meaning more patients experienced hypoglycemia (BG ≤ 3.5 mmol/L; CON n = 3 vs INT n = 2) but less hyperglycemia (BG ≥ 10.9 mmol/L; CON n = 0 vs INT n = 6) under CON. |
PMID:24593125 DOI:10.1111/sms.12192 |
2015 Scandinavian journal of medicine & science in sports |
* Simulated games activity vs continuous running exercise: a novel comparison of the glycemic and metabolic responses in T1DM patients. |
- To compare the glycemic and metabolic responses to simulated intermittent games activity and continuous running exercise in type 1 diabetes. Nine patients (seven male, two female; 35 ± 4 years; HbA1c 8.1 ± 0.2%/65 ± 2 mmol/mol) treated on a basal-bolus regimen completed two main trials, a continuous treadmill run (CON) or an intermittent running protocol (INT). Patients arrived to the laboratory fasted at ∼ 08:00 h, replicating their usual pre-exercise meal and administering a 50% reduced dose of rapid-acting insulin before exercising. Blood glucose (BG), K(+) , Na(++) , pH, triglycerides, serum cortisol and NEFA were measured at baseline and for 60 min post-exercise. Interstitial glucose was measured for a further 23 h under free-living conditions. Following exercise, BG declined under both conditions but was less under INT (INT -1.1 ± 1.4 vs CON -5.3 ± 0.4 mmol/L, P = 0.037), meaning more patients experienced hypoglycemia (BG ≤ 3.5 mmol/L; CON n = 3 vs INT n = 2) but less hyperglycemia (BG ≥ 10.9 mmol/L; CON n = 0 vs INT n = 6) under CON. Blood lactate was significantly greater, and pH lower, with a temporal delay in K(+) under INT (P < 0.05). No conditional differences were observed in other measures during this time, or in interstitial glucose concentrations during the remaining 23 h after exercise. Simulated games activity carries a lower risk of early, but not late-onset hypoglycemia than continuous running exercise in type 1 diabetes. |
(1)95 the | (18)4 these | (35)2 axial | (52)2 of |
(2)13 different | (19)3 high | (36)2 censoring | (53)2 optimal |
(3)12 a | (20)3 investigation | (37)2 clinical | (54)2 physiological |
(4)9 general | (21)3 light | (38)2 consideration | (55)2 pulsatile |
(5)8 both | (22)3 local | (39)2 controlled | (56)2 scanning |
(6)8 which | (23)3 mechanical | (40)2 current | (57)2 serum-free |
(7)7 various | (24)2 *null* | (41)2 evaluation | (58)2 several |
(8)6 conditions | (25)2 12 | (42)2 ex | (59)2 simulated |
(9)6 curve | (26)2 15 | (43)2 extreme | (60)2 specific |
(10)6 static | (27)2 2 | (44)2 four | (61)2 steady-state |
(11)5 and | (28)2 CA | (45)2 hypertensive | (62)2 therapy |
(12)4 5 | (29)2 CT | (46)2 hypoxia | (63)2 this |
(13)4 certain | (30)2 H2O2-induced | (47)2 hypoxic | (64)2 time |
(14)4 control | (31)2 UV | (48)2 inflammatory | (65)2 treatment |
(15)4 either | (32)2 acute | (49)2 laser | (66)2 ultrasound |
(16)4 in | (33)2 additive | (50)2 lateral | (67)2 vertical |
(17)4 normal | (34)2 adverse | (51)2 mortality | (68)2 water |
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