ELIZA

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321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [no cache] 500 found

200) Under these conditions, a level-A in vitro-in vivo correlation was suggested (r = 0.9926).

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PMID:24517572 DOI:10.3109/03639045.2014.884128

2015 Drug development and industrial pharmacy

* Gemifloxacin mesylate (GFM): dissolution test based on in vivo data.

- Gemifloxacin mesylate (GFM) is a synthetic, broad-spectrum, fluoroquinolone antibacterial agent. It is different from other class members because it achieves adequate plasma concentrations to inhibit both topoisomerase IV and gyrase. The aim of this study was to develop and validate a dissolution test for GFM in coated tablets, using a simulated absorption profile based on in vivo data obtained from the literature. The fraction and percentage of the dose absorbed were calculated using model-dependent Loo-Riegelman approach for two compartments. The best in vitro dissolution profile was obtained using 900 mL of pH 6.0 phosphate buffer as a dissolution medium at 37 °C ± 0.5 °C and paddles at 50 rpm. The in vitro dissolution samples were analyzed using a liquid chromatography method, and the validation was performed according to USP 34 (2011). The method showed specificity, precision, accuracy, robustness and linearity. Under these conditions, a level-A in vitro-in vivo correlation was suggested (r = 0.9926). The prediction errors were calculated to determine the validity and accuracy of the suggested correlation. The dissolution test can be used to evaluate the dissolution profile of GFM-coated tablets and minimize the number of bioavailability studies as part of new formulation development.

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(1)95 the	(18)4 these	(35)2 axial	(52)2 of
(2)13 different	(19)3 high	(36)2 censoring	(53)2 optimal
(3)12 a	(20)3 investigation	(37)2 clinical	(54)2 physiological
(4)9 general	(21)3 light	(38)2 consideration	(55)2 pulsatile
(5)8 both	(22)3 local	(39)2 controlled	(56)2 scanning
(6)8 which	(23)3 mechanical	(40)2 current	(57)2 serum-free
(7)7 various	(24)2 null	(41)2 evaluation	(58)2 several
(8)6 conditions	(25)2 12	(42)2 ex	(59)2 simulated
(9)6 curve	(26)2 15	(43)2 extreme	(60)2 specific
(10)6 static	(27)2 2	(44)2 four	(61)2 steady-state
(11)5 and	(28)2 CA	(45)2 hypertensive	(62)2 therapy
(12)4 5	(29)2 CT	(46)2 hypoxia	(63)2 this
(13)4 certain	(30)2 H2O2-induced	(47)2 hypoxic	(64)2 time
(14)4 control	(31)2 UV	(48)2 inflammatory	(65)2 treatment
(15)4 either	(32)2 acute	(49)2 laser	(66)2 ultrasound
(16)4 in	(33)2 additive	(50)2 lateral	(67)2 vertical
(17)4 normal	(34)2 adverse	(51)2 mortality	(68)2 water

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---