ELIZA

return kwic search for under out of >500 occurrences
321496 occurrences (No.66 in the rank) during 5 years in the PubMed. [no cache] 500 found

23) According to the bioequivalence guidelines, the area under the blood concentration - time curve by 48 hours after administration (AUC0-48) in a single intravenous drip (IVD) study, and AUC0-48 and maximum blood concentration (Cmax) in a single subcutaneous (SC) dose study were used as primary endpoints, and the pharmacodynamic parameters including absolute neutrophil count (ANC) or number of CD34 positive cells (CD34(+) cells) as secondary endpoints.

--- ABSTRACT ---

PMID:24471477 DOI:10.3109/03639045.2013.879721

2015 Drug development and industrial pharmacy

* Pharmacokinetics and pharmacodynamics of FSK0808 and Gran after single intravenous drip administration or single subcutaneous administration: comparative study in healthy Japanese adult male subjects.

- FSK0808 is a recombinant human granulocyte colony-stimulating factor developed by Fuji Pharma Co., Ltd and Mochida Pharmaceutical Co., Ltd. as a biosimilar product of Gran®. We verified the pharmacokinetic/pharmacodynamic equivalence of FSK0808 and commercially available Gran® by a randomized crossover study of single intravenous dose (200 µg/m(2)) and single subcutaneous dose (400 µg/m(2)) in healthy Japanese adult male subjects. According to the bioequivalence guidelines, the area under the blood concentration - time curve by 48 hours after administration (AUC0-48) in a single intravenous drip (IVD) study, and AUC0-48 and maximum blood concentration (Cmax) in a single subcutaneous (SC) dose study were used as primary endpoints, and the pharmacodynamic parameters including absolute neutrophil count (ANC) or number of CD34 positive cells (CD34(+) cells) as secondary endpoints. The safety was evaluated based on the characteristics and incidence of adverse reactions. As a result, the 90% confidence interval (CI) of the difference in mean value for AUC0-48 among drugs ranged from log(0.8) to log(1.25), in the IVD study, and those for Cmax and AUC0-48 were within the range of log(0.8)-log(1.25) in the SC study. Those for secondary endpoints were all within the range of log(0.8)-log(1.25). Thus, the pharmacokinetics/pharmacodynamics of both drugs were considered equivalent for all routes of administration, and the profiles of adverse reactions were also very similar.

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[frequency of next (right) word to under]

(1)95 the	(18)4 these	(35)2 axial	(52)2 of
(2)13 different	(19)3 high	(36)2 censoring	(53)2 optimal
(3)12 a	(20)3 investigation	(37)2 clinical	(54)2 physiological
(4)9 general	(21)3 light	(38)2 consideration	(55)2 pulsatile
(5)8 both	(22)3 local	(39)2 controlled	(56)2 scanning
(6)8 which	(23)3 mechanical	(40)2 current	(57)2 serum-free
(7)7 various	(24)2 null	(41)2 evaluation	(58)2 several
(8)6 conditions	(25)2 12	(42)2 ex	(59)2 simulated
(9)6 curve	(26)2 15	(43)2 extreme	(60)2 specific
(10)6 static	(27)2 2	(44)2 four	(61)2 steady-state
(11)5 and	(28)2 CA	(45)2 hypertensive	(62)2 therapy
(12)4 5	(29)2 CT	(46)2 hypoxia	(63)2 this
(13)4 certain	(30)2 H2O2-induced	(47)2 hypoxic	(64)2 time
(14)4 control	(31)2 UV	(48)2 inflammatory	(65)2 treatment
(15)4 either	(32)2 acute	(49)2 laser	(66)2 ultrasound
(16)4 in	(33)2 additive	(50)2 lateral	(67)2 vertical
(17)4 normal	(34)2 adverse	(51)2 mortality	(68)2 water

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--- WordNet output for under --- =>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に Overview of adj under The adj under has 2 senses (first 2 from tagged texts) 1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under parts of a machine") 2. (1) under -- (lower in rank, power, or authority; "an under secretary") Overview of adv under The adv under has 8 senses (first 1 from tagged texts) 1. (2) under -- (down to defeat, death, or ruin; "their competitors went under") 2. under -- (through a range downward; "children six and under will be admitted free") 3. under -- (into unconsciousness; "this will put the patient under") 4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment under") 5. under -- (below some quantity or limit; "fifty dollars or under") 6. under -- (below the horizon; "the sun went under") 7. under -- (down below; "get under quickly!") 8. under, below -- (further down; "see under for further discussion") --- WordNet end ---