* Mucoadhesive polyethylenimine-dextran sulfate nanoparticles containing Punica granatum peel extract as a novel sustained-release antimicrobial.
- Mucoadhesive polyethylenimine-dextran sulfate nanoparticles (PDNPs) were developed for local oral mucosa delivery. Punica granatum peel extract (PGE) was loaded into PDNPs for oral malodor reduction and caries prevention. PDNPs were constructed using the polyelectrolyte complexation technique employing oppositely charged polymers polyethylenimine (PEI) and dextran sulfate (DS), with PEG 400 as a stabilizer. Under optimal conditions, spherical particles of ∼ 500 nm with a zeta potential of ∼+28 mV were produced. Up to 98%, drug entrapment efficiency was observed. The mass ratio of PEI:DS played a significant role in controlling particle size and entrapment efficacy. PDNPs shown to be a good mucoadhesive drug delivery system as confirmed by ex vivo wash off test. In vitro dissolution studies revealed that PGE-loaded PDNPs manifested a prolong release characteristic with a burst release within 5 min. In addition, they remained effectively against oral bacteria.
=>以下の, (治療, 試練, 刑罰)を受けて, 下部の, の下に, ・・の下に
Overview of adj under
The adj under has 2 senses (first 2 from tagged texts)
1. (2) nether, under -- (located below or beneath something else; "nether garments"; "the under
parts of a machine")
2. (1) under -- (lower in rank, power, or authority; "an under secretary")
Overview of adv under
The adv under has 8 senses (first 1 from tagged texts)
1. (2) under -- (down to defeat, death, or ruin; "their competitors went under")
2. under -- (through a range downward; "children six and under will be admitted free")
3. under -- (into unconsciousness; "this will put the patient under")
4. under -- (in or into a state of subordination or subjugation; "we must keep our disappointment
under")
5. under -- (below some quantity or limit; "fifty dollars or under")
6. under -- (below the horizon; "the sun went under")
7. under -- (down below; "get under quickly!")
8. under, below -- (further down; "see under for further discussion")
--- WordNet end ---