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309) The high genomic similarities (but certainly not completely identical) between the EAC cell lines and their original tumors provide rational for their use.
2015 Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus
* Translational research on esophageal adenocarcinoma: from cell line to clinic.
- Human esophageal adenocarcinoma (EAC) cell lines have made a substantial contribution to elucidating mechanisms of carcinogenesis and drug discovery. Model research on EAC relies almost entirely on a relatively small set of established tumor cell lines because appropriate animal models are lacking. Nowadays, more than 20% of all fundamental translational research studies regarding EAC are partially or entirely based on these cell lines. The ready availability of these cell lines to investigators worldwide have resulted in more than 250 publications, including many examples of important biomedical discoveries. The high genomic similarities (but certainly not completely identical) between the EAC cell lines and their original tumors provide rational for their use. Recently, in a collaborative effort all available EAC cell lines have been verified resulting in the establishment of a reliable panel of 10 EAC cell lines. It could be expected that the value of these cell lines increases as unlimited source of tumor material because new biomedical techniques require more tumor cells and the supply of viable tumor cells is diminishing because of neoadjuvant chemo(radio)therapy of patients with EAC. Here, we review the history of the EAC cell lines and their utility in translational research and biomedical discovery.
=>利用, 使う, 利用する, (体, 能力など)を働かす, 使用, 利用法
Overview of noun use
The noun use has 7 senses (first 6 from tagged texts)
1. (90) use, usage, utilization, utilisation, employment, exercise -- (the act of using; "he warned
against the use of narcotic drugs"; "skilled in the utilization of computers")
2. (18) function, purpose, role, use -- (what something is used for; "the function of an auger is to
bore holes"; "ballet is beautiful but what use is it?")
3. (7) use -- (a particular service; "he put his knowledge to good use"; "patrons have their uses")
4. (1) consumption, economic consumption, usance, use, use of goods and services -- ((economics) the
utilization of economic goods to satisfy needs or in manufacturing; "the consumption of energy has
increased steadily")
5. (1) habit, use -- ((psychology) an automatic pattern of behavior in reaction to a specific
situation; may be inherited or acquired through frequent repetition; "owls have nocturnal habits";
"she had a habit twirling the ends of her hair"; "long use had hardened him to it")
6. (1) manipulation, use -- (exerting shrewd or devious influence especially for one's own
advantage; "his manipulation of his friends was scandalous")
7. use, enjoyment -- ((law) the exercise of the legal right to enjoy the benefits of owning
property; "we were given the use of his boat")
Overview of verb use
The verb use has 6 senses (first 3 from tagged texts)
1. (603) use, utilize, utilise, apply, employ -- (put into service; make work or employ for a
particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at
home"; "I can't use this tool"; "Apply a magnetic field here"; "This thinking was applied to many
projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the
plastic bags to store the food"; "He doesn't know how to use a computer")
2. (12) use, habituate -- (take or consume (regularly or habitually); "She uses drugs rarely")
3. (8) use, expend -- (use up, consume fully; "The legislature expended its time on school
questions")
4. use -- (seek or achieve an end by using to one's advantage; "She uses her influential friends to
get jobs"; "The president's wife used her good connections")
5. practice, apply, use -- (avail oneself to; "apply a principle"; "practice a religion"; "use care
when going down the stairs"; "use your common sense"; "practice non-violent resistance")
6. use -- (habitually do something (use only in the past tense); "She used to call her mother every
week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall";
"They used to vacation in the Bahamas")
--- WordNet end ---