ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for use out of >500 occurrences
821596 occurrences (No.5 in the rank) during 5 years in the PubMed. [no cache] 500 found
432) Since many households use Cu tubing in the plumbing system, and corrosion causes the metal to leach into the drinking water, there may be adverse effects on the central nervous system connected with low-level chronic exposure.
--- ABSTRACT ---
PMID:23719850 DOI:10.1177/0748233713491805
2015 Toxicology and industrial health
* Low concentrations of copper in drinking water increase AP-1 binding in the brain.
- Copper (Cu) in trace amounts is essential for biological organisms. However, dysregulation of the redox-active metal has been implicated in different neurological disorders such as Wilson's, Menkes', Alzheimer's, and Parkinson's diseases. Since many households use Cu tubing in the plumbing system, and corrosion causes the metal to leach into the drinking water, there may be adverse effects on the central nervous system connected with low-level chronic exposure. The present study demonstrates that treatment with a biologically relevant concentration of Cu for 3 months significantly increases activation of the redox-modulated transcription factor AP-1 in mouse brains. This was independent of an upstream kinase indicated in AP-1 activation. Another redox-active transcription factor, NF-κB, was not significantly modified by the Cu exposure. These results indicate that the effect of Cu on AP-1 is unique and may involve direct modulation of DNA binding.
--- ABSTRACT END ---
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(1)263 of (8)5 is (15)3 by (22)2 at
(2)34 in (9)5 was (16)3 it (23)2 has
(3)24 *null* (10)5 with (17)3 these (24)2 therapeutic
(4)24 and (11)4 a (18)3 were (25)2 to
(5)8 the (12)4 among (19)3 when (26)2 visual
(6)5 as (13)3 are (20)2 TAA
(7)5 for (14)3 because (21)2 acculturation,

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--- WordNet output for use --- =>利用, 使う, 利用する, (体, 能力など)を働かす, 使用, 利用法 Overview of noun use The noun use has 7 senses (first 6 from tagged texts) 1. (90) use, usage, utilization, utilisation, employment, exercise -- (the act of using; "he warned against the use of narcotic drugs"; "skilled in the utilization of computers") 2. (18) function, purpose, role, use -- (what something is used for; "the function of an auger is to bore holes"; "ballet is beautiful but what use is it?") 3. (7) use -- (a particular service; "he put his knowledge to good use"; "patrons have their uses") 4. (1) consumption, economic consumption, usance, use, use of goods and services -- ((economics) the utilization of economic goods to satisfy needs or in manufacturing; "the consumption of energy has increased steadily") 5. (1) habit, use -- ((psychology) an automatic pattern of behavior in reaction to a specific situation; may be inherited or acquired through frequent repetition; "owls have nocturnal habits"; "she had a habit twirling the ends of her hair"; "long use had hardened him to it") 6. (1) manipulation, use -- (exerting shrewd or devious influence especially for one's own advantage; "his manipulation of his friends was scandalous") 7. use, enjoyment -- ((law) the exercise of the legal right to enjoy the benefits of owning property; "we were given the use of his boat") Overview of verb use The verb use has 6 senses (first 3 from tagged texts) 1. (603) use, utilize, utilise, apply, employ -- (put into service; make work or employ for a particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at home"; "I can't use this tool"; "Apply a magnetic field here"; "This thinking was applied to many projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the plastic bags to store the food"; "He doesn't know how to use a computer") 2. (12) use, habituate -- (take or consume (regularly or habitually); "She uses drugs rarely") 3. (8) use, expend -- (use up, consume fully; "The legislature expended its time on school questions") 4. use -- (seek or achieve an end by using to one's advantage; "She uses her influential friends to get jobs"; "The president's wife used her good connections") 5. practice, apply, use -- (avail oneself to; "apply a principle"; "practice a religion"; "use care when going down the stairs"; "use your common sense"; "practice non-violent resistance") 6. use -- (habitually do something (use only in the past tense); "She used to call her mother every week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall"; "They used to vacation in the Bahamas") --- WordNet end ---