ELIZA cgi-bash version rev. 1.90
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435) Therefore, the present study aimed to use FN immunoreactivity (FN-ir) as a marker for early detection of rheumatic susceptible children with palatine tonsil crypts surface epithelium.
* Fibronectin in the palatine tonsil as a susceptibility marker in Egyptian rheumatic families: histological and immunohistochemical studies.
- Rheumatic fever (RF) and rheumatic heart disease (RHD) are the multisystem autoimmune sequel of group A streptococci (GAS) infection of the upper respiratory passages, mainly tonsillopharyngitis. The major receptor on the surface of human palatine tonsil for GAS is fibronectin (FN; adhesin receptor). Early detection of RF susceptibility is considered as an important aim of this study. Therefore, the present study aimed to use FN immunoreactivity (FN-ir) as a marker for early detection of rheumatic susceptible children with palatine tonsil crypts surface epithelium. A total of 30 palatine tonsillar specimens were obtained from children aged from 3 to 15 years. Histological studies showed moderate vascular changes and more than four apparent epithelial disruptions in the crypt epithelium. FN-ir showed a significant increase in FN in the basal layers of surface epithelium, subepithelial connective tissue and interfollicular areas. Tonsils of children in rheumatic families showed significant increase in FN in subepithelial connective tissue areas with more than one apparent crypt epithelial disruption compared to normal children. We can conclude that FN plays a central role in the RF and differentially distributed in the functional compartments of the palatine tonsil in children with RHD, so FN-ir can be used as a marker for rheumatic susceptibility.
=>利用, 使う, 利用する, (体, 能力など)を働かす, 使用, 利用法
Overview of noun use
The noun use has 7 senses (first 6 from tagged texts)
1. (90) use, usage, utilization, utilisation, employment, exercise -- (the act of using; "he warned
against the use of narcotic drugs"; "skilled in the utilization of computers")
2. (18) function, purpose, role, use -- (what something is used for; "the function of an auger is to
bore holes"; "ballet is beautiful but what use is it?")
3. (7) use -- (a particular service; "he put his knowledge to good use"; "patrons have their uses")
4. (1) consumption, economic consumption, usance, use, use of goods and services -- ((economics) the
utilization of economic goods to satisfy needs or in manufacturing; "the consumption of energy has
increased steadily")
5. (1) habit, use -- ((psychology) an automatic pattern of behavior in reaction to a specific
situation; may be inherited or acquired through frequent repetition; "owls have nocturnal habits";
"she had a habit twirling the ends of her hair"; "long use had hardened him to it")
6. (1) manipulation, use -- (exerting shrewd or devious influence especially for one's own
advantage; "his manipulation of his friends was scandalous")
7. use, enjoyment -- ((law) the exercise of the legal right to enjoy the benefits of owning
property; "we were given the use of his boat")
Overview of verb use
The verb use has 6 senses (first 3 from tagged texts)
1. (603) use, utilize, utilise, apply, employ -- (put into service; make work or employ for a
particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at
home"; "I can't use this tool"; "Apply a magnetic field here"; "This thinking was applied to many
projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the
plastic bags to store the food"; "He doesn't know how to use a computer")
2. (12) use, habituate -- (take or consume (regularly or habitually); "She uses drugs rarely")
3. (8) use, expend -- (use up, consume fully; "The legislature expended its time on school
questions")
4. use -- (seek or achieve an end by using to one's advantage; "She uses her influential friends to
get jobs"; "The president's wife used her good connections")
5. practice, apply, use -- (avail oneself to; "apply a principle"; "practice a religion"; "use care
when going down the stairs"; "use your common sense"; "practice non-violent resistance")
6. use -- (habitually do something (use only in the past tense); "She used to call her mother every
week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall";
"They used to vacation in the Bahamas")
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