ELIZA cgi-bash version rev. 1.91
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for used to out of >500 occurrences
298981 occurrences (No.78 in the rank) during 5 years in the PubMed. [cache]
134) Because of the lack of Cre recombinase lines that are specific for innate-like T cells, pan-T cell Cre lines are often used to study innate-like T cells.
--- ABSTRACT ---
PMID:34583938 DOI:10.4049/immunohorizons.2100079
2021 ImmunoHorizons
* Distal Lck Promoter-Driven Cre Shows Cell Type-Specific Function in Innate-like T Cells.
- Innate-like T cells, including invariant NKT cells, mucosal-associated invariant T (MAIT) cells, and γ δ T (γδT) cells, are groups of unconventional T lymphocytes. They play important roles in the immune system. Because of the lack of Cre recombinase lines that are specific for innate-like T cells, pan-T cell Cre lines are often used to study innate-like T cells. In this study, we found that distal Lck promoter-driven Cre (dLckCre) in which the distal Lck gene promoter drives Cre expression in the late stage of thymocyte development has limited function in the innate-like T cells using ROSA26floxed-Stop-tdTomato reporter. Innate-like T cells differentiate into mature functional subsets comparable to the CD4+ Th subsets under homeostatic conditions. We further showed that dLckCre-expressing γδT cells are strongly biased toward γδT1 phenotype. Interestingly, the γδT cells residing in the epidermis and comprising the vast majority of dendritic epidermal T cells nearly all express dLckCre, indicating dLckCre is a useful tool for studying dendritic epidermal T cells. Taken together, these data suggest that Lck distal promoter has different activity in the conventional and unconventional T cells. The use of dLCKcre transgenic mice in the innate-like T cells needs to be guided by a reporter for the dLckCre function.
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[frequency of next (right) word to used to]
(1)44 identify (17)7 improve (33)4 select (49)2 gauge
(2)32 assess (18)6 compare (34)4 validate (50)2 increase
(3)20 evaluate (19)6 create (35)3 analyse (51)2 knock
(4)19 treat (20)6 inform (36)3 collect (52)2 make
(5)14 predict (21)6 test (37)3 construct (53)2 manipulate
(6)14 study (22)6 understand (38)3 demonstrate (54)2 monitor
(7)13 measure (23)5 address (39)3 explore (55)2 overcome
(8)12 investigate (24)4 calculate (40)3 help (56)2 perform
(9)11 determine (25)4 conduct (41)3 induce (57)2 provide
(10)11 examine (26)4 define (42)3 mimic (58)2 reduce
(11)11 guide (27)4 deliver (43)2 acquire (59)2 refer
(12)10 analyze (28)4 describe (44)2 better (60)2 simulate
(13)9 estimate (29)4 detect (45)2 characterize (61)2 track
(14)9 quantify (30)4 generate (46)2 confirm
(15)9 support (31)4 obtain (47)2 design
(16)8 develop (32)4 search (48)2 enhance

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--- WordNet output for used --- =>1.〜に慣れて, 2.用いられた, 中古の Overview of verb use The verb use has 6 senses (first 3 from tagged texts) 1. (603) use, utilize, utilise, apply, employ -- (put into service; make work or employ for a particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at home"; "I can't use this tool"; "Apply a magnetic field here"; "This thinking was applied to many projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the plastic bags to store the food"; "He doesn't know how to use a computer") 2. (12) use, habituate -- (take or consume (regularly or habitually); "She uses drugs rarely") 3. (8) use, expend -- (use up, consume fully; "The legislature expended its time on school questions") 4. use -- (seek or achieve an end by using to one's advantage; "She uses her influential friends to get jobs"; "The president's wife used her good connections") 5. practice, apply, use -- (avail oneself to; "apply a principle"; "practice a religion"; "use care when going down the stairs"; "use your common sense"; "practice non-violent resistance") 6. use -- (habitually do something (use only in the past tense); "She used to call her mother every week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall"; "They used to vacation in the Bahamas") Overview of adj used The adj used has 3 senses (first 3 from tagged texts) 1. (4) used -- (employed in accomplishing something; "the principle of surprise is the most used and misused of all the principles of war"- H.H.Arnold & I.C.Eaker) 2. (1) exploited, ill-used, put-upon, used, victimized, victimised -- (of persons; taken advantage of; "after going out of his way to help his friend get the job he felt not appreciated but used") 3. (1) secondhand, used -- (previously used or owned by another; "bought a secondhand (or used) car") --- WordNet end ---