119) While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. |
PMID:24041870 DOI:10.1016/j.canlet.2013.09.009 |
2015 Cancer letters |
* Non-targeted effects induced by ionizing radiation: mechanisms and potential impact on radiation induced health effects. |
- Not-targeted effects represent a paradigm shift from the "DNA centric" view that ionizing radiation only elicits biological effects and subsequent health consequences as a result of an energy deposition event in the cell nucleus. While this is likely true at higher radiation doses (>1 Gy), at low doses (<100 mGy) non-targeted effects associated with radiation exposure might play a significant role. Here definitions of non-targeted effects are presented, the potential mechanisms for the communication of signals and signaling networks from irradiated cells/tissues are proposed, and the various effects of this intra- and intercellular signaling are described. We conclude with speculation on how these observations might lead to and impact long-term human health outcomes. |
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(2)14 in | (17)3 its | (32)2 focusing | (47)2 providing |
(3)13 no | (18)3 most | (33)2 for | (48)2 receiving |
(4)11 a | (19)3 others | (34)2 further | (49)2 serum |
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(7)4 maintaining | (22)3 these | (37)2 minimising | (52)2 similar |
(8)4 one | (23)3 those | (38)2 much | (53)2 slightly |
(9)4 performing | (24)3 women | (39)2 negative | (54)2 some |
(10)4 reducing | (25)2 Asians | (40)2 numerous | (55)2 still |
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(12)4 simultaneously | (27)2 also | (42)2 other | (57)2 their |
(13)4 they | (28)2 controlling | (43)2 participants | |
(14)4 using | (29)2 digging/gardening, | (44)2 preserving | |
(15)3 20% | (30)2 downregulation | (45)2 previous |
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