ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for while out of >500 occurrences
341393 occurrences (No.55 in the rank) during 5 years in the PubMed. [no cache] 500 found
177) The tumor expression level of Ki67 was increased while that of the cleaved caspase 3 and the ER-β and progesterone receptors was reduced.
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PMID:24038423 DOI:10.1002/mc.22074
2015 Molecular carcinogenesis
* Dietary fat without body weight gain increases in vivo MCF-7 human breast cancer cell growth and decreases natural killer cell cytotoxicity.
- High-calorie (HC) diet contributes to the increased incidence of obesity, which is a risk factor for breast cancer in postmenopausal women, and in particular for estrogen receptor (ER) positive tumors. This study investigated whether an HC diet increases human ER-positive breast cancer progression and modulates natural killer (NK) cell functions. Four-week-old female BALB/c athymic nude mice were fed a HC diet (5320 kcal/kg) or standard calorie diet (SC, 2820 kcal/kg) for 6 mo. After 5 mo, the mice were randomly implanted with MCF-7 breast cancer cells (SCT and HCT) or received an isovolumic injection (SC and HC) in both inguinal fat pads. Tumor growth was greater in the HCT group than in the SC group without change in body weight. The HC diet decreased the tumor expression of genes involved in the citrate cycle and in adiponectin and lipid metabolism but increased that of genes controlling glycolysis and angiogenesis. The tumor expression level of Ki67 was increased while that of the cleaved caspase 3 and the ER-β and progesterone receptors was reduced. Tumor development in response to the HC diet was associated with smaller numbers and lower cytotoxicity of splenic NK cells. These results indicate that an HC diet without body weight gain increases ER-positive breast cancer cell proliferation and reduces tumor apoptosis. The underlying mechanisms might involve a downexpression of tumor hormonal receptor and reduced NK cell functions, and might also result in the regulation of genes involved in several cellular functions.
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(1)79 the (16)3 it (31)2 environmental (46)2 promoting
(2)14 in (17)3 its (32)2 focusing (47)2 providing
(3)13 no (18)3 most (33)2 for (48)2 receiving
(4)11 a (19)3 others (34)2 further (49)2 serum
(5)6 this (20)3 that (35)2 harvesting (50)2 she
(6)4 at (21)3 there (36)2 increasing (51)2 significant
(7)4 maintaining (22)3 these (37)2 minimising (52)2 similar
(8)4 one (23)3 those (38)2 much (53)2 slightly
(9)4 performing (24)3 women (39)2 negative (54)2 some
(10)4 reducing (25)2 Asians (40)2 numerous (55)2 still
(11)4 retaining (26)2 accounting (41)2 on (56)2 subcutaneous
(12)4 simultaneously (27)2 also (42)2 other (57)2 their
(13)4 they (28)2 controlling (43)2 participants
(14)4 using (29)2 digging/gardening, (44)2 preserving
(15)3 20% (30)2 downregulation (45)2 previous

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--- WordNet output for while --- =>時間と労働, その間に, 時間, する間に, なのに, そのうえ, をのんびりと過す Overview of noun while The noun while has 1 sense (first 1 from tagged texts) 1. (23) while, piece, spell, patch -- (a period of indeterminate length (usually short) marked by some action or condition; "he was here for a little while"; "I need to rest for a piece"; "a spell of good weather"; "a patch of bad weather") --- WordNet end ---