186) Dogs with T-cell lymphoma had an ORR of 55% for a median of 60 days (range 49-858 days) while those with B-cell lymphoma had an ORR of 57% for a median of 81 days (range 7-274 days) (P = 0.783). |
PMID:23910023 DOI:10.1111/vco.12055 |
2015 Veterinary and comparative oncology |
* Mechlorethamine, vincristine, melphalan and prednisone (MOMP) for the treatment of relapsed lymphoma in dogs. |
- Eighty-eight dogs with relapsed lymphoma were treated with the MOMP (mechlorethamine, vincristine, melphalan and prednisone) protocol on a 28-day treatment cycle. The overall response rate (ORR) to the MOMP protocol was 51.1% for a median of 56 days (range 7-858 days). Twelve percent of dogs experienced a complete response for a median of 81 days (range 42-274 days) and 38.6% experienced a partial response for a median of 49 days (range 7-858 days). Dogs with T-cell lymphoma had an ORR of 55% for a median of 60 days (range 49-858 days) while those with B-cell lymphoma had an ORR of 57% for a median of 81 days (range 7-274 days) (P = 0.783). The overall survival time for all dogs was 183 days (range 17-974 days). Fifty-four percent of dogs experienced toxicity with the majority classified as grade I. The MOMP protocol seems well-tolerated and is an option for dogs with relapsed lymphoma. |
(1)79 the | (16)3 it | (31)2 environmental | (46)2 promoting |
(2)14 in | (17)3 its | (32)2 focusing | (47)2 providing |
(3)13 no | (18)3 most | (33)2 for | (48)2 receiving |
(4)11 a | (19)3 others | (34)2 further | (49)2 serum |
(5)6 this | (20)3 that | (35)2 harvesting | (50)2 she |
(6)4 at | (21)3 there | (36)2 increasing | (51)2 significant |
(7)4 maintaining | (22)3 these | (37)2 minimising | (52)2 similar |
(8)4 one | (23)3 those | (38)2 much | (53)2 slightly |
(9)4 performing | (24)3 women | (39)2 negative | (54)2 some |
(10)4 reducing | (25)2 Asians | (40)2 numerous | (55)2 still |
(11)4 retaining | (26)2 accounting | (41)2 on | (56)2 subcutaneous |
(12)4 simultaneously | (27)2 also | (42)2 other | (57)2 their |
(13)4 they | (28)2 controlling | (43)2 participants | |
(14)4 using | (29)2 digging/gardening, | (44)2 preserving | |
(15)3 20% | (30)2 downregulation | (45)2 previous |
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