222) This is the longest reported follow-up of a patient being off steroids while on MMF. |
PMID:24075023 DOI:10.5414/CN108025 |
2015 Clinical nephrology |
* Mycophenolate mofetil as a steroid-sparing agent in sarcoid-associated renal disease. |
- Steroids are the mainstay of treatment for renal sarcoidosis. Many patients with sarcoidosis are chronically dependent on steroids and there is limited data on the use of steroid-sparing agents. This is a case of a patient that has remained in remission using mycophenolate mofetil (MMF) as a steroid-sparing agent. The patient is a 56-year-old female with a history of sarcoidosis diagnosed by lymph node biopsy who developed 3 episodes of acute kidney injury (AKI) in the setting of exacerbations of her sarcoidosis, each responding to prednisone treatment. Due to possible lifelong need for prednisone, MMF was started as a steroid-sparing treatment. She tolerated the MMF well and has now been steroidfree for 22 months. There have been only a few case reports about the use of MMF as a steroid-sparing agent in sarcoid-associated renal disease, in which patients could be successfully weaned off steroids. This is the longest reported follow-up of a patient being off steroids while on MMF. It is also notable for the patient having a relapse on the MMF which responded to an increased dose. MMF should be studied further as a potential steroid-sparing agent in the treatment of sarcoid associated renal disease. |
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(7)4 maintaining | (22)3 these | (37)2 minimising | (52)2 similar |
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(14)4 using | (29)2 digging/gardening, | (44)2 preserving | |
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