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272943 occurrences (No.93 in the rank) during 5 years in the PubMed. [no cache]
500 found
130) 5-lipoxygenase (5-LOX), a member of the lipoxygenase gene family, is a key enzyme assisting in the conversion of arachidonic acid to 5-HETE and leukotrienes.
* Increased metabolites of 5-lipoxygenase from hypoxic ovarian cancer cells promote tumor-associated macrophage infiltration.
- 5-lipoxygenase (5-LOX), a member of the lipoxygenase gene family, is a key enzyme assisting in the conversion of arachidonic acid to 5-HETE and leukotrienes. Tumor-associated macrophages (TAMs) have a critical role in the progression and metastasis of many tumors, including ovarian tumors. Moreover, TAMs are often found in a high density in the hypoxic areas of tumors. However, the relevant mechanisms have not been studied explicitly until now. In this study, we found that the expression of 5-LOX strongly correlated with the density of TAMs in hypoxic areas of human ovarian tumor tissues. In cultured ovarian cancer cells, 5-LOX metabolites were increased under hypoxic conditons. Increased 5-LOX metabolites from hypoxic ovarian cancer cells promoted migration and invasion of macrophages, which was further demonstrated to be mediated by the upregulation of matrix metalloproteinase (MMP)-7 expression through the p38 pathway. Besides, we also showed that 5-LOX metabolites enhanced the release of tumor necrosis factor (TNF-α) and heparin-binding epidermal growth factor-like growth factor through upregulation of MMP-7. Furthermore, in animal models, Zileuton (a selective and specific 5-LOX inhibitor) reduced the MMP-7 expression and the number of macrophages infiltrating in the xenograft. Our findings suggest for the first time that increased metabolites of 5-LOX from hypoxic ovarian cancer cells promote TAM infiltration. These results of this study have immediate translational implications for the therapeutic exploitation of TAMs.
=>1.酸っぱい, 2.辛辣な, 3.酸, 4.《俗語》麻薬, LSD
Overview of noun acid
The noun acid has 2 senses (first 1 from tagged texts)
1. (4) acid -- (any of various water-soluble compounds having a sour taste and capable of turning
litmus red and reacting with a base to form a salt)
2. acid, back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds,
pane, superman, window pane, Zen -- (street name for lysergic acid diethylamide)
Overview of adj acid
The adj acid has 3 senses (first 1 from tagged texts)
1. (1) acerb, acerbic, acid, acrid, bitter, blistering, caustic, sulfurous, sulphurous, virulent,
vitriolic -- (harsh or corrosive in tone; "an acerbic tone piercing otherwise flowery prose"; "a
barrage of acid comments"; "her acrid remarks make her many enemies"; "bitter words"; "blistering
criticism"; "caustic jokes about political assassination, talk-show hosts and medical ethics"; "a
sulfurous denunciation"; "a vitriolic critique")
2. acidic, acid, acidulent, acidulous -- (being sour to the taste)
3. acid -- (having the characteristics of an acid; "an acid reaction")
--- WordNet end ---