205) Higher intakes of fish and n-3 polyunsaturated fatty acids (n-3PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are associated with a reduced risk of coronary artery disease (CAD). |
PMID:24309896 DOI:10.1007/s00380-013-0442-y |
2015 Heart and vessels |
* Association of atherosclerosis-related markers and its relationship to n-3 polyunsaturated fatty acids levels with a prevalence of coronary artery disease in an urban area in Japan. |
- Higher intakes of fish and n-3 polyunsaturated fatty acids (n-3PUFAs: eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) are associated with a reduced risk of coronary artery disease (CAD). We investigated the relationships between fish-derived n-3PUFAs and prevalence of CAD, and to assess the association of n-3PUFAs with atherosclerosis-related markers in an urban area. This study was designed as a hospital-based cross-sectional study on 649 consecutive outpatients who had undergone regular examinations between April 2009 and October 2009. After adjustments for the coronary risk factors in a multilogistic regression analysis of variables for which a significant difference was identified between the group of patients with a prevalence of CAD and the group with no prevalence of CAD, the multivariable odds ratio (95 % confidence interval) was 0.394 (0.205/0.760; P = 0.005) for the highest (92.4-373.5 μg/ml) versus lowest (6.2-40.0 μg/ml) quartile of serum EPA values and 0.433 (0.228/0.824; P = 0.011) for the highest (160.7-451.8 μg/ml) versus lowest (35.7-100.7 μg/ml) quartile of serum DHA values. Multivariate regression analyses after adjustment for risk factors showed that higher serum EPA and DHA levels were independent variables of a higher level of serum apolipoprotein A-1, a major compound of high-density lipoprotein. However, the results suggested that there might be conflicting effects of EPA and DHA in regard of the serum levels of other lipid markers. This cross-sectional study suggests that higher serum levels of n-3PUFAs were associated with a lower prevalence of CAD and an increase in serum apolipoprotein A-1 level, even in an urban area. |
(1)29 and | (20)4 treatment | (39)2 (FA) | (58)2 from |
(2)15 *null* | (21)3 (AA) | (40)2 (PA) | (59)2 hydrolysis |
(3)11 in | (22)3 (ALA) | (41)2 (PLGA) | (60)2 interactions |
(4)10 phenethyl | (23)3 (GABA) | (42)2 (PLGA), | (61)2 may |
(5)10 phosphatase | (24)3 (NEFA) | (43)2 (SA) | (62)2 nanoparticles |
(6)9 is | (25)3 changes | (44)2 (SLA) | (63)2 peptide |
(7)8 was | (26)3 decarboxylase | (45)2 (TA) | (64)2 proteins |
(8)6 (HA) | (27)3 etching | (46)2 (TCA) | (65)2 racemization |
(9)6 reactive | (28)3 levels | (47)2 A | (66)2 ratio |
(10)5 as | (29)3 metabolism | (48)2 BSA | (67)2 residues |
(11)5 bacteria | (30)3 on | (49)2 Ig-superfamily | (68)2 substances |
(12)5 group | (31)3 protein | (50)2 Schiff | (69)2 suppressive |
(13)5 or | (32)3 sequence | (51)2 biosynthesis | (70)2 synthetase |
(14)5 synthesis | (33)3 sequences | (52)2 by | (71)2 the |
(15)5 to | (34)3 status | (53)2 changes, | (72)2 therapy |
(16)4 binding | (35)3 were | (54)2 composition | (73)2 vitamin |
(17)4 derivatives | (36)2 (DHA) | (55)2 contents | |
(18)4 for | (37)2 (EDTA) | (56)2 cycle | |
(19)4 solution | (38)2 (EPA) | (57)2 extract |
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