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return kwic search for acid out of >500 occurrences
272943 occurrences (No.93 in the rank) during 5 years in the PubMed. [no cache] 500 found

56) Metabolism (fatty acid oxidation and oxidative phosphorylation) in PT cells showed the strongest and most reproducible association with PT cell differentiation and disease.

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PMID:33301705 DOI:10.1016/j.cmet.2020.11.011

2021 Cell metabolism

* The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.

- Kidney disease is poorly understood because of the organ's cellular diversity. We used single-cell RNA sequencing not only in resolving differences in injured kidney tissue cellular composition but also in cell-type-specific gene expression in mouse models of kidney disease. This analysis highlighted major changes in cellular diversity in kidney disease, which markedly impacted whole-kidney transcriptomics outputs. Cell-type-specific differential expression analysis identified proximal tubule (PT) cells as the key vulnerable cell type. Through unbiased cell trajectory analyses, we show that PT cell differentiation is altered in kidney disease. Metabolism (fatty acid oxidation and oxidative phosphorylation) in PT cells showed the strongest and most reproducible association with PT cell differentiation and disease. Coupling of cell differentiation and the metabolism was established by nuclear receptors (estrogen-related receptor alpha [ESRRA] and peroxisomal proliferation-activated receptor alpha [PPARA]) that directly control metabolic and PT-cell-specific gene expression in mice and patient samples while protecting from kidney disease in the mouse model.

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[frequency of next (right) word to acid]

(1)26 and	(19)3 (GABA)	(37)2 (AMPA)	(55)2 glycoprotein
(2)13 metabolism	(20)3 (HA)	(38)2 (ASA)	(56)2 group
(3)11 null	(21)3 A,	(39)2 (BA)	(57)2 have
(4)10 oxidation	(22)3 Gels	(40)2 (FA)	(58)2 injury
(5)9 receptor	(23)3 amide	(41)2 (GABA)ergic	(59)2 ion
(6)8 in	(24)3 amplification	(42)2 (HAuCl4)	(60)2 is
(7)7 residues	(25)3 ceramidase	(43)2 (IAA),	(61)2 layer
(8)6 cycle	(26)3 delivery	(44)2 (OCA),	(62)2 mutations
(9)6 transporter	(27)3 moiety	(45)2 (TCA)	(63)2 positions
(10)6 was	(28)3 protein	(46)2 Amide	(64)2 quantification
(11)5 or	(29)3 protein,	(47)2 alone	(65)2 regulation
(12)5 sequence	(30)3 receptors	(48)2 binding	(66)2 substitution
(13)4 biosynthesis	(31)3 reduced	(49)2 biosensor	(67)2 synthesis
(14)4 composition	(32)3 regurgitation	(50)2 burns	(68)2 the
(15)4 levels	(33)3 sequences	(51)2 cargo	(69)2 transporter,
(16)4 metabolism,	(34)3 transport	(52)2 changes	(70)2 variants
(17)4 structures	(35)3 transporters	(53)2 diethylamide	(71)2 wet
(18)4 substitutions	(36)3 were	(54)2 from

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--- WordNet output for acid --- =>1.酸っぱい, 2.辛辣な, 3.酸, 4.《俗語》麻薬, LSD Overview of noun acid The noun acid has 2 senses (first 1 from tagged texts) 1. (4) acid -- (any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt) 2. acid, back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen -- (street name for lysergic acid diethylamide) Overview of adj acid The adj acid has 3 senses (first 1 from tagged texts) 1. (1) acerb, acerbic, acid, acrid, bitter, blistering, caustic, sulfurous, sulphurous, virulent, vitriolic -- (harsh or corrosive in tone; "an acerbic tone piercing otherwise flowery prose"; "a barrage of acid comments"; "her acrid remarks make her many enemies"; "bitter words"; "blistering criticism"; "caustic jokes about political assassination, talk-show hosts and medical ethics"; "a sulfurous denunciation"; "a vitriolic critique") 2. acidic, acid, acidulent, acidulous -- (being sour to the taste) 3. acid -- (having the characteristics of an acid; "an acid reaction") --- WordNet end ---