ELIZA

return kwic search for activity out of >500 occurrences
475194 occurrences (No.33 in the rank) during 5 years in the PubMed. [cache]

186) Lofexidine decreased heroin intake, reinstatement, and motor activity.

--- ABSTRACT ---

PMID:34955731 DOI:10.3389/fnins.2021.784365

2021 Frontiers in neuroscience

* Complex Interactions Between Sex and Stress on Heroin Seeking.

- Rationale: Stress plays a dual role in substance use disorders as a precursor to drug intake and a relapse precipitant. With heroin use at epidemic proportions in the United States, understanding interactions between stress disorders and opioid use disorder is vital and will aid in treatment of these frequently comorbid conditions. Objectives: Here, we combine assays of stress and contingent heroin self-administration (SA) to study behavioral adaptations in response to stress and heroin associated cues in male and female rats. Methods: Rats underwent acute restraint stress paired with an odor stimulus and heroin SA for subsequent analysis of stress and heroin cue reactivity. Lofexidine was administered during heroin SA and reinstatement testing to evaluate its therapeutic potential. Rats also underwent tests on the elevated plus maze, locomotor activity in a novel environment, and object recognition memory following stress and/or heroin. Results: A history of stress and heroin resulted in disrupted behavior on multiple levels. Stress rats avoided the stress conditioned stimulus and reinstated heroin seeking in response to it, with males reinstating to a greater extent than females. Lofexidine decreased heroin intake, reinstatement, and motor activity. Previous heroin exposure increased time spent in the closed arms of an elevated plus maze, activity in a round novel field, and resulted in object recognition memory deficits. Discussion: These studies report that a history of stress and heroin results in maladaptive coping strategies and suggests a need for future studies seeking to understand circuits recruited in this pathology and eventually help develop therapeutic approaches.

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(1)69 and	(13)5 are	(25)3 interventions	(37)2 effect;
(2)46 of	(14)5 or	(26)3 limitations	(38)2 for
(3)45 in	(15)5 relationship	(27)3 models	(39)2 has
(4)44 null	(16)5 with	(28)3 opportunities	(40)2 increased
(5)14 was	(17)4 and/or	(29)3 programs	(41)2 levels
(6)13 against	(18)4 at	(30)3 sedentary	(42)2 levels,
(7)12 (PA)	(19)4 may	(31)3 that	(43)2 plays
(8)10 is	(20)3 (PA),	(32)3 through	(44)2 programmes
(9)7 as	(21)3 advice	(33)2 appears	(45)2 using
(10)6 by	(22)3 but	(34)2 assessment
(11)6 during	(23)3 changes	(35)2 counselling
(12)6 on	(24)3 compared	(36)2 differentiation

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--- WordNet output for activity --- =>活動, 活躍, 働き, 動き, 活気 Overview of noun activity The noun activity has 6 senses (first 3 from tagged texts) 1. (43) activity -- (any specific behavior; "they avoided all recreational activity") 2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is out of action") 3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes place in the body; "respiratory activity") 4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction; "catalytic activity") 5. natural process, natural action, action, activity -- (a process existing in or produced by nature (rather than by the intent of human beings); "the action of natural forces"; "volcanic activity") 6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically; "the level of activity declines with age") --- WordNet end ---