2015 Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
* Inhibition of Binding of β2-Glycoprotein 1 to Phosphatidylserine by Polymyxin B, a Lupus-Like Anticoagulant.
- Polymyxin B is a cationic peptide that inhibits phospholipid-dependent coagulation tests including activated partial thromboplastin time and to a lesser degree prothrombin time. Thrombin clotting time is insensitive to polymyxin B. β2-glycoprotein 1 (β2GP1) is a cofactor of antiphospholipid antibodies. Antiphospholipid autoantibodies also poses lupus anticoagulant activity through interactions with β2GP1. Using affinity chromatography, polymyxin B can effectively decrease the binding of β2GP1 to immobilize phosphatidylserine. Since then, anticoagulant effect of polymyxin B is most likely due to the binding to negatively charged phospholipids, preventing formation of coagulation complexes.
=>活動, 活躍, 働き, 動き, 活気
Overview of noun activity
The noun activity has 6 senses (first 3 from tagged texts)
1. (43) activity -- (any specific behavior; "they avoided all recreational activity")
2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is
out of action")
3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes
place in the body; "respiratory activity")
4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction;
"catalytic activity")
5. natural process, natural action, action, activity -- (a process existing in or produced by nature
(rather than by the intent of human beings); "the action of natural forces"; "volcanic activity")
6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically;
"the level of activity declines with age")
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