* Combining rosuvastatin with angiotensin-receptor blockers of different PPARγ-activating capacity: effects on high-density lipoprotein subfractions and associated enzymes.
- The effects of combining angiotensin-receptor blockers of different peroxisome proliferator-activated receptor γ-activating capacity with rosuvastatin on high-density lipoprotein (HDL) subfractions and associated enzymes in patients with mixed dyslipidemia, hypertension, and prediabetes were assessed. Patients (n = 151) were randomly allocated to rosuvastatin (10 mg/d) plus telmisartan 80 mg/d (RT group, n = 52) or irbesartan 300 mg/d (RI group, n = 48) or olmesartan 20 mg/d (RO group, n = 51). Total and intermediate HDL cholesterol (HDL-C) levels did not change in any group. Large HDL-C increased, while small HDL-C decreased significantly in all the groups (P = not significant between the groups). The mass of HDL lipoprotein-associated phospholipase A2 (HDL-Lp-PLA2) and the activities of paraoxonase 1 remained unchanged in all the groups. However, HDL-Lp-PLA2 activity increased only in the RT group (+21.4%; P < .01 vs baseline) and did not change in the RI (-4.3%; P = .005 vs RT group) and RO (+3.2%; P = .01 vs RT) groups. In conclusion, only the combination of rosuvastatin with telmisartan increased the possibly antiatherosclerotic HDL-Lp-PLA2 activity.
=>活動, 活躍, 働き, 動き, 活気
Overview of noun activity
The noun activity has 6 senses (first 3 from tagged texts)
1. (43) activity -- (any specific behavior; "they avoided all recreational activity")
2. (36) action, activity, activeness -- (the state of being active; "his sphere of activity"; "he is
out of action")
3. (13) bodily process, body process, bodily function, activity -- (an organic process that takes
place in the body; "respiratory activity")
4. activity -- ((chemistry) the capacity of a substance to take part in a chemical reaction;
"catalytic activity")
5. natural process, natural action, action, activity -- (a process existing in or produced by nature
(rather than by the intent of human beings); "the action of natural forces"; "volcanic activity")
6. activeness, activity -- (the trait of being active; moving or acting rapidly and energetically;
"the level of activity declines with age")
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