ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for analysis out of >500 occurrences
560012 occurrences (No.18 in the rank) during 5 years in the PubMed. [no cache] 500 found
26) Transcriptional profile analysis of E14.5 Arx-ablated cortices compared with control revealed that CDKN1C, an inhibitor of cell cycle progression, is overexpressed in the cortical VZ and SVZ of Arx KOs throughout corticogenesis.
--- ABSTRACT ---
PMID:23968833 DOI:10.1093/cercor/bht222
2015 Cerebral cortex (New York, N.Y. : 1991)
* ARX regulates cortical intermediate progenitor cell expansion and upper layer neuron formation through repression of Cdkn1c.
- Mutations in the Aristaless-related homeobox (ARX) gene are found in a spectrum of epilepsy and X-linked intellectual disability disorders. During development Arx is expressed in pallial ventricular zone (VZ) progenitor cells where the excitatory projection neurons of the cortex are born. Arx(-/Y) mice were shown to have decreased proliferation in the cortical VZ resulting in smaller brains; however, the basis for this reduced proliferation was not established. To determine the role of ARX on cell cycle dynamics in cortical progenitor cells, we generated cerebral cortex-specific Arx mouse mutants (cKO). The loss of pallial Arx resulted in the reduction of cortical progenitor cells, particularly the proliferation of intermediate progenitor cells (IPCs) was affected. Later in development and postnatally cKO brains showed a reduction of upper layer but not deeper layer neurons consistent with the IPC defect. Transcriptional profile analysis of E14.5 Arx-ablated cortices compared with control revealed that CDKN1C, an inhibitor of cell cycle progression, is overexpressed in the cortical VZ and SVZ of Arx KOs throughout corticogenesis. We also identified ARX as a direct regulator of Cdkn1c transcription. Together these data support a model where ARX regulates the expansion of cortical progenitor cells through repression of Cdkn1c.
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(1)124 of (12)7 is (23)3 suggested (34)2 method
(2)63 *null* (13)6 with (24)3 we (35)2 no
(3)35 was (14)5 based (25)3 yielded (36)2 patients
(4)22 and (15)5 on (26)2 (FEA) (37)2 results
(5)21 showed (16)5 were (27)2 allele (38)2 reveals
(6)19 revealed (17)4 as (28)2 because (39)2 suggests
(7)10 in (18)4 confirmed (29)2 by (40)2 that
(8)9 indicated (19)4 demonstrated (30)2 during (41)2 tools
(9)8 the (20)4 using (31)2 found
(10)8 to (21)3 identified (32)2 further
(11)7 for (22)3 shows (33)2 has

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--- WordNet output for analysis --- =>詳細な検討, 分解, 分析, 解析, 見方, 精神分析 Overview of noun analysis The noun analysis has 6 senses (first 3 from tagged texts) 1. (45) analysis -- (an investigation of the component parts of a whole and their relations in making up the whole) 2. (5) analysis, analytic thinking -- (the abstract separation of a whole into its constituent parts in order to study the parts and their relations) 3. (2) analysis -- (a form of literary criticism in which the structure of a piece of writing is analyzed) 4. analysis -- (the use of closed-class words instead of inflections: e.g., `the father of the bride' instead of `the bride's father') 5. analysis -- (a branch of mathematics involving calculus and the theory of limits; sequences and series and integration and differentiation) 6. psychoanalysis, analysis, depth psychology -- (a set of techniques for exploring underlying motives and a method of treating various mental disorders; based on the theories of Sigmund Freud; "his physician recommended psychoanalysis") --- WordNet end ---