* Sequence polymorphisms in the D-loop region of mitochondrial DNA and outcome of non-Hodgkin lymphoma.
- Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) might be associated with cancer risk and disease outcome. We have identified 140 SNPs including 26 SNPs with frequency distribution of minor allele greater than 5% in a case-control study for non-Hodgkin lymphoma patients previously. In this study, we assessed the predictive power of D-loop SNPs in NHL patients. Five SNP sites were identified by log-rank test for statistically significant prediction of NHL survival in a univariate analysis. In an overall multivariate analysis, allele 16304 was identified as an independent predictor of NHL outcome. The survival time of NHL patients with 16304C was significantly shorter than that of patients with 16304T (relative risk, 0.513; 95% CI, 0.266-0.989; p = 0.046). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify subgroups of patients who are at a high risk of a poor disease outcome.
=>詳細な検討, 分解, 分析, 解析, 見方, 精神分析
Overview of noun analysis
The noun analysis has 6 senses (first 3 from tagged texts)
1. (45) analysis -- (an investigation of the component parts of a whole and their relations in
making up the whole)
2. (5) analysis, analytic thinking -- (the abstract separation of a whole into its constituent parts
in order to study the parts and their relations)
3. (2) analysis -- (a form of literary criticism in which the structure of a piece of writing is
analyzed)
4. analysis -- (the use of closed-class words instead of inflections: e.g., `the father of the
bride' instead of `the bride's father')
5. analysis -- (a branch of mathematics involving calculus and the theory of limits; sequences and
series and integration and differentiation)
6. psychoanalysis, analysis, depth psychology -- (a set of techniques for exploring underlying
motives and a method of treating various mental disorders; based on the theories of Sigmund Freud;
"his physician recommended psychoanalysis")
--- WordNet end ---