* Single nucleotide polymorphisms in the D-loop region of mitochondrial DNA is associated with renal cell carcinoma outcome.
- Accumulation of single nucleotide polymorphisms (SNPs) in the displacement loop (D-loop) of mitochondrial DNA (mtDNA) has been described in various types of cancers and might be associated with cancer risk and disease outcome. We identified 14 SNPs with a frequency higher than 5% and 5 SNPs associated with the risk of renal cell carcinoma (RCC) in a case-control study previously. In the present study, we assessed the relationship of these SNPs and the outcome of RCC patients, a SNP of 262C/T was identified by the log-rank test for statistically significant prediction of RCC survival. In an overall multivariate analysis, allele 262 was identified as an independent predictor of RCC outcome. The length of survival of patients with 262T was significantly shorter than that of patients with allele 262C (relative risk, 2.136, 95%CI, 1.863-2.449; p = 0.000). The analysis of genetic polymorphisms in the mitochondrial D-loop can help identify patients subgroup at high risk of a poor disease outcome.
=>詳細な検討, 分解, 分析, 解析, 見方, 精神分析
Overview of noun analysis
The noun analysis has 6 senses (first 3 from tagged texts)
1. (45) analysis -- (an investigation of the component parts of a whole and their relations in
making up the whole)
2. (5) analysis, analytic thinking -- (the abstract separation of a whole into its constituent parts
in order to study the parts and their relations)
3. (2) analysis -- (a form of literary criticism in which the structure of a piece of writing is
analyzed)
4. analysis -- (the use of closed-class words instead of inflections: e.g., `the father of the
bride' instead of `the bride's father')
5. analysis -- (a branch of mathematics involving calculus and the theory of limits; sequences and
series and integration and differentiation)
6. psychoanalysis, analysis, depth psychology -- (a set of techniques for exploring underlying
motives and a method of treating various mental disorders; based on the theories of Sigmund Freud;
"his physician recommended psychoanalysis")
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