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657704 occurrences (No.10 in the rank) during 5 years in the PubMed. [cache]

428) These results indicate that sustained cannabis abstinence significantly reduces the number of sperm showing cannabis-associated alterations at genes important for early development.

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PMID:34557312 DOI:10.1093/eep/dvab009

2021 Environmental epigenetics

* Refraining from use diminishes cannabis-associated epigenetic changes in human sperm.

- Cannabis use alters sperm DNA methylation, but the potential reversibility of these changes is unknown. Semen samples from cannabis users and non-user controls were collected at baseline and again following a 77-day period of cannabis abstinence (one spermatogenic cycle). Users and controls did not significantly differ by demographics or semen analyses. Whole-genome bisulfite sequencing identified 163 CpG sites with significantly different DNA methylation in sperm between groups (P < 2.94 × 10^-9). Genes associated with altered CpG sites were enriched with those involved in development, including cardiogenesis and neurodevelopment. Many of the differences in sperm DNA methylation between groups were diminished after cannabis abstinence. These results indicate that sustained cannabis abstinence significantly reduces the number of sperm showing cannabis-associated alterations at genes important for early development.

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(1)376 with	(6)3 risk	(11)2 immune	(16)2 osteosarcoma
(2)4 diseases	(7)2 at	(12)2 liver	(17)2 receptor
(3)4 genes	(8)2 cancers	(13)2 lymphoid
(4)4 protein	(9)2 common	(14)2 macrophage
(5)3 genes,	(10)2 diarrhoea	(15)2 molecular

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--- WordNet output for associated --- Overview of verb associate The verb associate has 3 senses (first 3 from tagged texts) 1. (25) associate, tie in, relate, link, colligate, link up, connect -- (make a logical or causal connection; "I cannot connect these two pieces of evidence in my mind"; "colligate these facts"; "I cannot relate these events at all") 2. (3) consort, associate, affiliate, assort -- (keep company with; hang out with; "He associates with strange people"; "She affiliates with her colleagues") 3. (1) consociate, associate -- (bring or come into association or action; "The churches consociated to fight their dissolution") --- WordNet end ---