ELIZA

return kwic search for cancer out of >500 occurrences
505522 occurrences (No.25 in the rank) during 5 years in the PubMed. [cache]

188) The presence of K-Ras mutations not only has prognostic value, but it also predicts the responsiveness of colon cancer patients to inhibitors of EGFR signaling.

--- ABSTRACT ---

PMID:24219000 DOI:10.1089/hum.2013.171

2015 Current clinical pharmacology

* K-Ras, intestinal homeostasis and colon cancer.

- Activating Ras mutations, present in about 20% of human cancers, compromise the GTPase activity of Ras and therefore trigger accumulation of Ras in the GTP-bound state. Among the three family members, K-Ras, H-Ras and N-Ras, K-Ras is the most frequently mutated gene, with 30-50% of colon cancer patients harboring activating K-Ras mutations. Oncogenic mutations of K-Ras have been found at codons 12, 13, 61 and 146. Activation of Ras triggers constitutive activation of signaling pathways, including the MAPK and AKT pathways, which allows tumor cells to proliferate in the absence of growth factors and increases their survival. In addition, activated Ras triggers inflammation and thus promotes tumor progression in a cell non-autonomous manner. The presence of K-Ras mutations not only has prognostic value, but it also predicts the responsiveness of colon cancer patients to inhibitors of EGFR signaling.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to cancer]

(1)65 null	(14)6 therapy	(27)3 of	(40)2 epigenetics
(2)48 cells	(15)6 tissues	(28)3 patients,	(41)2 growth
(3)33 and	(16)5 cells,	(29)3 research	(42)2 initiation
(4)32 cell	(17)5 progression	(30)3 was	(43)2 prevention
(5)23 patients	(18)5 registries	(31)2 (GC)	(44)2 registry
(6)15 in	(19)4 at	(32)2 biology	(45)2 study
(7)14 is	(20)4 deaths	(33)2 but	(46)2 susceptibility
(8)12 risk	(21)4 has	(34)2 can	(47)2 than
(9)12 screening	(22)4 mortality	(35)2 care	(48)2 treated
(10)12 stem	(23)3 (CRC)	(36)2 development	(49)2 treatment
(11)9 survivors	(24)3 as	(37)2 diagnostic	(50)2 using
(12)7 with	(25)3 cases	(38)2 drug
(13)6 are	(26)3 metabolism	(39)2 drugs

add keyword

--- WordNet output for cancer --- =>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌 Overview of noun cancer The noun cancer has 5 senses (first 1 from tagged texts) 1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream) 2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer) 3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini) 4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22) 5. Cancer, genus Cancer -- (type genus of the family Cancridae) --- WordNet end ---