ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cancer out of >500 occurrences
505522 occurrences (No.25 in the rank) during 5 years in the PubMed. [no cache] 500 found
309) The CDK inhibitor p27(kip1) plays crucial roles in cell cycle regulation and cancer progression.
--- ABSTRACT ---
PMID:24336329 DOI:10.1038/onc.2013.536
2015 Oncogene
* MIF4G domain containing protein regulates cell cycle and hepatic carcinogenesis by antagonizing CDK2-dependent p27 stability.
- The CDK inhibitor p27(kip1) plays crucial roles in cell cycle regulation and cancer progression. Through yeast two-hybrid screening, we identified MIF4G domain containing protein (MIF4GD) as a novel binding partner for p27. The association of MIF4GD and p27 was verified using immunoprecipitation and glutathione S-transferase (GST) pull-down assays. Interaction with MIF4GD led to the stabilization of p27 both in the nucleus and in the cytoplasm in hepatocellular carcinoma (HCC) cells as a result of suppressed phosphorylation of p27 by CDK2 at threonine187. Serum stimulation decreased the levels of MIF4GD and p27 simultaneously. In addition, MIF4GD overexpression resulted in increased p27 levels and reduced cell proliferation, while knockdown of MIF4GD promoted cell cycle progression with decreased p27 levels in cells. Furthermore, overexpression of MIF4GD reduced colony formation and inhibited xenograft tumor growth in nude mice. Finally, we found that both MIF4GD and p27 were expressed at low levels in HCC tissues compared to non-cancerous tissues, and that low expression levels of MIF4GD and p27 were associated with significantly worse prognosis in HCC patients. Our results suggest that MIF4GD is a potential regulator of p27-dependent cell proliferation in HCC. These findings provide a rational framework for the development of potential HCC therapy by targeting the MIF4GD-p27 interaction.
--- ABSTRACT END ---
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[frequency of next (right) word to cancer]
(1)65 *null* (14)6 therapy (27)3 of (40)2 epigenetics
(2)48 cells (15)6 tissues (28)3 patients, (41)2 growth
(3)33 and (16)5 cells, (29)3 research (42)2 initiation
(4)32 cell (17)5 progression (30)3 was (43)2 prevention
(5)23 patients (18)5 registries (31)2 (GC) (44)2 registry
(6)15 in (19)4 at (32)2 biology (45)2 study
(7)14 is (20)4 deaths (33)2 but (46)2 susceptibility
(8)12 risk (21)4 has (34)2 can (47)2 than
(9)12 screening (22)4 mortality (35)2 care (48)2 treated
(10)12 stem (23)3 (CRC) (36)2 development (49)2 treatment
(11)9 survivors (24)3 as (37)2 diagnostic (50)2 using
(12)7 with (25)3 cases (38)2 drug
(13)6 are (26)3 metabolism (39)2 drugs

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--- WordNet output for cancer --- =>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌 Overview of noun cancer The noun cancer has 5 senses (first 1 from tagged texts) 1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal and uncontrolled cell division; it may spread to other parts of the body through the lymphatic system or the blood stream) 2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer) 3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini) 4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22) 5. Cancer, genus Cancer -- (type genus of the family Cancridae) --- WordNet end ---