* p53 orchestrates between normal differentiation and cancer.
- During recent years, it is becoming more and more evident that there is a tight connection between abnormal differentiation processes and cancer. While cancer and stem cells are very different, especially in terms of maintaining genomic integrity, these cell types also share many similar properties. In this review, we aim to provide an over-view of the roles of the key tumor suppressor, p53, in regulating normal differentiation and function of both stem cells and adult cells. When these functions are disrupted, undifferentiated cells may become transformed. Understanding the function of p53 in stem cells and its role in maintaining the balance between differentiation and malignant transformation can help shed light on cancer initiation and propagation, and hopefully also on cancer prevention and therapy.
=>【病名】がん, 悪性腫瘍(しゅよう), がん腫, 社会悪, 癌
Overview of noun cancer
The noun cancer has 5 senses (first 1 from tagged texts)
1. (15) cancer, malignant neoplastic disease -- (any malignant growth or tumor caused by abnormal
and uncontrolled cell division; it may spread to other parts of the body through the lymphatic
system or the blood stream)
2. Cancer, Crab -- ((astrology) a person who is born while the sun is in Cancer)
3. Cancer -- (a small zodiacal constellation in the northern hemisphere; between Leo and Gemini)
4. Cancer, Cancer the Crab, Crab -- (the fourth sign of the zodiac; the sun is in this sign from
about June 21 to July 22)
5. Cancer, genus Cancer -- (type genus of the family Cancridae)
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