ELIZA

return kwic search for cell out of >500 occurrences
928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [cache]

10) In vivo experiments furthermore demonstrated successful tumour regression in mice treated with chimeric antibody receptor T cells in which the expression of programmed cell death protein 1 (PD1) is downregulated after nanofibre photoporation with short interfering RNA to PD1.

--- ABSTRACT ---

PMID:34675410 DOI:10.1038/s41565-021-00976-3

2021 Nature nanotechnology

* Photothermal nanofibres enable safe engineering of therapeutic cells.

- Nanoparticle-sensitized photoporation is an upcoming approach for the intracellular delivery of biologics, combining high efficiency and throughput with excellent cell viability. However, as it relies on close contact between nanoparticles and cells, its translation towards clinical applications is hampered by safety and regulatory concerns. Here we show that light-sensitive iron oxide nanoparticles embedded in biocompatible electrospun nanofibres induce membrane permeabilization by photothermal effects without direct cellular contact with the nanoparticles. The photothermal nanofibres have been successfully used to deliver effector molecules, including CRISPR-Cas9 ribonucleoprotein complexes and short interfering RNA, to adherent and suspension cells, including embryonic stem cells and hard-to-transfect T cells, without affecting cell proliferation or phenotype. In vivo experiments furthermore demonstrated successful tumour regression in mice treated with chimeric antibody receptor T cells in which the expression of programmed cell death protein 1 (PD1) is downregulated after nanofibre photoporation with short interfering RNA to PD1. In conclusion, cell membrane permeabilization with photothermal nanofibres is a promising concept towards the safe and more efficient production of engineered cells for therapeutic applications, including stem cell or adoptive T cell therapy.

--- ABSTRACT END ---

[
right
kwic]

[frequency of next (right) word to cell]

(1)23 death	(18)5 differentiation	(35)3 envelope	(52)2 immunity
(2)15 lines	(19)5 infiltration	(36)3 function	(53)2 informative
(3)15 types	(20)5 membrane	(37)3 growth	(54)2 interactions
(4)14 proliferation	(21)4 null	(38)3 lysis	(55)2 is
(5)14 wall	(22)4 activation	(39)3 migration	(56)2 killing
(6)8 carcinoma	(23)4 apoptosis	(40)3 mitochondrial	(57)2 malignancies
(7)8 transplantation	(24)4 culture	(41)3 shape	(58)2 manner
(8)7 line	(25)4 cultures	(42)3 therapy	(59)2 marker
(9)7 lung	(26)4 invasion	(43)2 DNA	(60)2 mass
(10)7 populations	(27)4 metabolism	(44)2 adhesion,	(61)2 migration,
(11)7 proliferation,	(28)4 receptor	(45)2 behavior	(62)2 mixture
(12)7 viability	(29)4 responses	(46)2 biology	(63)2 morphology
(13)6 surface	(30)4 type	(47)2 cholesterol	(64)2 nuclear
(14)6 survival	(31)3 RNA	(48)2 culture,	(65)2 number
(15)6 types,	(32)3 adhesion	(49)2 development	(66)2 over-activation,
(16)5 and	(33)3 cycle	(50)2 fate	(67)2 permeability
(17)5 cycle,	(34)3 division	(51)2 genes

add keyword

--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---