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928965 occurrences (No.3 in the rank) during 5 years in the PubMed. [no cache] 500 found

257) A large number of studies have evaluated the impact of TP53 mutations on the prognosis of patients with non-small cell lung cancer (NSCLC); however, the results of these studies are still controversial.

--- ABSTRACT ---

PMID:24038464 DOI:10.1002/mc.22077

2015 Molecular carcinogenesis

* The influence of TP53 mutations on the prognosis of patients with early stage non-small cell lung cancer may depend on the intratumor heterogeneity of the mutations.

- A large number of studies have evaluated the impact of TP53 mutations on the prognosis of patients with non-small cell lung cancer (NSCLC); however, the results of these studies are still controversial. Recently, considerable intratumor heterogeneity for genetic alterations has been demonstrated in various human cancers, including lung cancer. In the present study, we evaluated TP53 mutations in NSCLCs by direct sequencing and observed remarkable variation in the values of relative intensity (RI, the height of the peak of mutated allele/the height of the peak of non-mutated allele) of the mutations. We also examined whether the RI values were associated with intratumor heterogeneity of TP53 mutations. In addition, we evaluated the relationship between TP53 mutations and survival outcome. The patients with a TP53 mutation did not have significantly worse survival compared to those without the mutation. However, when tumors with a TP53 mutation were categorized into two groups, those with a low and those with a high RI, the latter group had significantly worse survival compared to those with wild-type TP53 (adjusted hazard ratio = 2.58, 95% confidence interval = 1.21-5.48, P = 0.01), whereas the former group did not. These results suggest that intratumor genetic heterogeneity may be an important factor in determining the role of TP53 mutations on the prognosis of NSCLC patients.

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(1)30 lines	(19)5 tumour	(37)3 migration	(55)2 lymphoma,
(2)16 death	(20)4 (RBC)	(38)3 response	(56)2 matrices
(3)15 proliferation	(21)4 growth	(39)3 scaffolds	(57)2 numbers
(4)15 viability	(22)4 markers	(40)3 source	(58)2 of
(5)13 lymphoma	(23)4 nuclear	(41)3 tumors	(59)2 printing
(6)12 and	(24)4 phenotype	(42)3 type	(60)2 responses
(7)9 carcinoma	(25)4 populations	(43)3 viability,	(61)2 seeding
(8)9 culture	(26)4 therapies	(44)2 activation	(62)2 survival
(9)9 sheets	(27)3 adhesion,	(45)2 aggregation	(63)2 system
(10)9 transplantation	(28)3 division	(46)2 attachment	(64)2 that
(11)9 types	(29)3 energy	(47)2 biology	(65)2 therapy,
(12)8 adhesion	(30)3 expansion	(48)2 coating,	(66)2 to
(13)8 cycle	(31)3 growth,	(49)2 death,	(67)2 transplantation,
(14)8 therapy	(32)3 immunity	(50)2 density	(68)2 tumours
(15)7 differentiation	(33)3 infiltration	(51)2 factors	(69)2 types,
(16)7 proliferation,	(34)3 line,	(52)2 genes	(70)2 volume
(17)6 surface	(35)3 lines,	(53)2 interactions	(71)2 wall
(18)5 line	(36)3 lung	(54)2 invasion	(72)2 was

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--- WordNet output for cell --- =>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房 Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---