* Therapeutic Potential of microRNA Modulation in Pulmonary Arterial Hypertension.
- MicroRNAs have emerged as key players of gene regulation during development and disease states like cancer and cardiovascular diseases. Pulmonary arterial hypertension (PAH), a vascular disease characterized by pulmonary resistance and vessel occlusion, is not spared by microRNA implication. This is not surprising since PAH shares common aberrantly activated pathways with cancers that lead to proliferation and survival of pulmonary arterial smooth muscle cells, among others, within the artery wall and narrowing the lumen. Recent studies demonstrated the role of miR-204 and miR- 206 in pulmonary artery smooth muscle cell (PASMC) proliferation. Other microRNAs, such as miR-145, miR-21 and the miR17/92 cluster, have been associated with the disrupted BMPR2 pathway. During the last couple of years, the number of studies on the role of microRNA in PAH has broadened, defining it clearly as a HOT TOPIC. This current review presents an overview of the most recent knowledge as well as future possibilities. The use of microRNA therapies is still uncertain and poorly applied in the clinical setting yet. It is still critical to increase the knowledge and the translational potential of this HOT TOPIC to make it become a HOPE TOPIC.
=>密室, 細胞, 電池, 独房・細胞, 監房, 組織, 独房
Overview of noun cell
The noun cell has 7 senses (first 3 from tagged texts)
1. (71) cell -- (any small compartment; "the cells of a honeycomb")
2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist
as independent units of life (as in monads) or may form colonies or tissues as in higher plants and
animals)
3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a
chemical reaction)
4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement)
5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile
radiotelephone for use in an area divided into small sections, each with its own short-range
transmitter/receiver)
6. cell, cubicle -- (small room in which a monk or nun lives)
7. cell, jail cell, prison cell -- (a room where a prisoner is kept)
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