ELIZA cgi-bash version rev. 1.90
- Medical English LInking keywords finder for the PubMed Zipped Archive (ELIZA) -

return kwic search for cells out of >500 occurrences
856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [no cache] 500 found
14) CECF significantly inhibited migration and invasion of U-2 OS human osteosarcoma cells.
--- ABSTRACT ---
PMID:23955962 DOI:10.1002/tox.21894
2015 Environmental toxicology
* The crude extract of Corni Fructus inhibits the migration and invasion of U-2 OS human osteosarcoma cells through the inhibition of matrix metalloproteinase-2/-9 by MAPK signaling.
- Osteosarcoma is the most common primary malignancy of the bone cancers. In the Chinese population, the crude extract of Corni Fructus (CECF) has been used as Traditional Chinese medicine to treat several different diseases for hundreds of years. In the present study, effects of CECF on inhibition of migration and invasion in U-2 OS human osteosarcoma cells were examined. CECF significantly inhibited migration and invasion of U-2 OS human osteosarcoma cells. We also found that CECF inhibited activities of matrix metalloproteinases-2 (MMP-2) and matrix metalloproteinases-9 (MMP-9). CECF decreased protein levels of FAK, PKC, SOS1, MKK7, MEKK3, GRB2, NF-κB p65, COX-2, HIF-1α, PI3K, Rho A, ROCK-1, IRE-1α, p-JNK1/2, p-ERK1/2, p-p38, Ras, p-PERK, MMP-2, MMP-9, and VEGF in U-2 OS cells. Results of this study indicate that CECF may have potential as a novel anticancer agent for the treatment of osteosarcoma by inhibiting migration and invasion of cancer cells.
--- ABSTRACT END ---
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[frequency of next (right) word to cells]
(1)80 *null* (15)5 as (29)3 exposed (43)2 expanded
(2)47 and (16)5 expressed (30)3 have (44)2 expressing
(3)39 were (17)5 of (31)3 isolated (45)2 had
(4)26 in (18)5 which (32)3 showed (46)2 labeled
(5)12 (MSCs) (19)4 (ASCs) (33)3 we (47)2 may
(6)11 was (20)4 has (34)2 (ASCs), (48)2 play
(7)10 to (21)4 is (35)2 (BMSCs) (49)2 present
(8)9 with (22)4 on (36)2 (ECFCs) (50)2 remains
(9)7 are (23)4 seeded (37)2 (HSCs) (51)2 such
(10)6 can (24)4 within (38)2 after (52)2 the
(11)6 for (25)3 (ASC) (39)2 by (53)2 via
(12)6 from (26)3 (ECs) (40)2 caused
(13)6 or (27)3 (HUVECs) (41)2 cultured
(14)6 that (28)3 (hMSCs) (42)2 derived

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---