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856246 occurrences (No.4 in the rank) during 5 years in the PubMed. [cache]

18) Disrupting spindle orientation in the placode, using mutations in either KIF18B or NuMA, results in aberrant cell fate marker expression of hair follicle progenitor cells.

--- ABSTRACT ---

PMID:34432485 DOI:10.1091/mbc.E21-06-0291

2021 Molecular biology of the cell

* KIF18B is a cell type-specific regulator of spindle orientation in the epidermis.

- Proper spindle orientation is required for asymmetric cell division and the establishment of complex tissue architecture. In the developing epidermis, spindle orientation requires a conserved cortical protein complex of LGN/NuMA/dynein-dynactin. However, how microtubule dynamics are regulated to interact with this machinery and properly position the mitotic spindle is not fully understood. Furthermore, our understanding of the processes that link spindle orientation during asymmetric cell division to cell fate specification in distinct tissue contexts remains incomplete. We report a role for the microtubule catastrophe factor KIF18B in regulating microtubule dynamics to promote spindle orientation in keratinocytes. During mitosis, KIF18B accumulates at the cell cortex, colocalizing with the conserved spindle orientation machinery. In vivo we find that KIF18B is required for oriented cell divisions within the hair placode, the first stage of hair follicle morphogenesis, but is not essential in the interfollicular epidermis. Disrupting spindle orientation in the placode, using mutations in either KIF18B or NuMA, results in aberrant cell fate marker expression of hair follicle progenitor cells. These data functionally link spindle orientation to cell fate decisions during hair follicle morphogenesis. Taken together, our data demonstrate a role for regulated microtubule dynamics in spindle orientation in epidermal cells. This work also highlights the importance of spindle orientation during asymmetric cell division to dictate cell fate specification.

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(1)86 null	(13)6 we	(25)3 during	(37)2 into
(2)61 and	(14)5 can	(26)3 have	(38)2 leads
(3)24 in	(15)5 is	(27)3 may	(39)2 regardless
(4)18 to	(16)5 treated	(28)3 using	(40)2 respectively
(5)13 are	(17)4 or	(29)2 (HBECs)	(41)2 show
(6)10 from	(18)4 revealed	(30)2 (HSCs)	(42)2 showed
(7)10 that	(19)4 was	(31)2 (OHCs)	(43)2 suggesting
(8)9 were	(20)4 while	(32)2 (PBMCs)	(44)2 supporting
(9)8 with	(21)3 (MSCs)	(33)2 at	(45)2 via
(10)7 of	(22)3 but	(34)2 could
(11)6 as	(23)3 by	(35)2 differentiate
(12)6 for	(24)3 derived	(36)2 including

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--- WordNet output for cells --- Overview of noun cell The noun cell has 7 senses (first 3 from tagged texts) 1. (71) cell -- (any small compartment; "the cells of a honeycomb") 2. (44) cell -- ((biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals) 3. (1) cell, electric cell -- (a device that delivers an electric current as the result of a chemical reaction) 4. cell, cadre -- (a small unit serving as part of or as the nucleus of a larger political movement) 5. cellular telephone, cellular phone, cellphone, cell, mobile phone -- (a hand-held mobile radiotelephone for use in an area divided into small sections, each with its own short-range transmitter/receiver) 6. cell, cubicle -- (small room in which a monk or nun lives) 7. cell, jail cell, prison cell -- (a room where a prisoner is kept) --- WordNet end ---