* Ascorbic acid inhibits ferric nitrilotriacetate induction of ornithine decarboxylase, DNA synthesis, oxidative stress, and hepatotoxicity in rats.
- Ascorbic acid (AA) is a naturally occurring phenolic compound with antioxidant properties used in food, cosmetics, and pharmaceutical products. In this study, the effect of AA on ferric nitrilotriacetate (Fe-NTA)-induced hepatotoxicity in rats has been examined. Fe-NTA alone enhances ornithine decarboxylase activity to 4.5-fold and tritiated thymidine incorporation in DNA to 3.6-fold in livers compared with the corresponding saline-treated controls. The enhanced ornithine decarboxylase activity and DNA synthesis showed a reduction to 3.02- and 1.88-fold, respectively, at a higher dose of 2 mg AA per day per animal, compared with the Fe-NTA-treated groups. Fe-NTA treatment also enhanced the hepatic microsomal lipid peroxidation to 1.7-fold compared to saline-treated controls. These changes were reversed significantly in animals receiving pretreatment of AA. The present data shows that AA can reciprocate the toxic effects of Fe-NTA and can serve as a potent chemopreventive agent to suppress oxidant-induced tissue injury and hepatotoxicity in rats.
Overview of noun change
The noun change has 10 senses (first 7 from tagged texts)
1. (46) change, alteration, modification -- (an event that occurs when something passes from one
state or phase to another; "the change was intended to increase sales"; "this storm is certainly a
change for the worse"; "the neighborhood had undergone few modifications since his last visit years
ago")
2. (45) change -- (a relational difference between states; especially between states before and
after some event; "he attributed the change to their marriage")
3. (17) change -- (the action of changing something; "the change of government had no impact on the
economy"; "his change on abortion cost him the election")
4. (13) change -- (the result of alteration or modification; "there were marked changes in the
lining of the lungs"; "there had been no change in the mountains")
5. (2) change -- (the balance of money received when the amount you tender is greater than the
amount due; "I paid with a twenty and pocketed the change")
6. (1) change -- (a thing that is different; "he inspected several changes before selecting one")
7. (1) change -- (a different or fresh set of clothes; "she brought a change in her overnight bag")
8. change -- (coins of small denomination regarded collectively; "he had a pocketful of change")
9. change -- (money received in return for its equivalent in a larger denomination or a different
currency; "he got change for a twenty and used it to pay the taxi driver")
10. variety, change -- (a difference that is usually pleasant; "he goes to France for variety"; "it
is a refreshing change to meet a woman mechanic")
Overview of verb change
The verb change has 10 senses (first 8 from tagged texts)
1. (57) change, alter, modify -- (cause to change; make different; cause a transformation; "The
advent of the automobile may have altered the growth pattern of the city"; "The discussion has
changed my thinking about the issue")
2. (54) change -- (undergo a change; become different in essence; losing one's or its original
nature; "She changed completely as she grew older"; "The weather changed last night")
3. (13) change, alter, vary -- (become different in some particular way, without permanently losing
one's or its former characteristics or essence; "her mood changes in accordance with the weather";
"The supermarket's selection of vegetables varies according to the season")
4. (7) switch, shift, change -- (lay aside, abandon, or leave for another; "switch to a different
brand of beer"; "She switched psychiatrists"; "The car changed lanes")
5. (6) change -- (change clothes; put on different clothes; "Change before you go to the opera")
6. (5) change, exchange, commute, convert -- (exchange or replace with another, usually of the same
kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert
centimeters into inches"; "convert holdings into shares")
7. (3) exchange, change, interchange -- (give to, and receive from, one another; "Would you change
places with me?"; "We have been exchanging letters for a year")
8. (3) transfer, change -- (change from one vehicle or transportation line to another; "She changed
in Chicago on her way to the East coast")
9. deepen, change -- (become deeper in tone; "His voice began to change when he was 12 years old";
"Her voice deepened when she whispered the password")
10. change -- (remove or replace the coverings of; "Father had to learn how to change the baby";
"After each guest we changed the bed linens")
--- WordNet end ---