ELIZA

return kwic search for changes out of >500 occurrences
332920 occurrences (No.57 in the rank) during 5 years in the PubMed. [cache]

426) In summary, there are age-related alterations to the structural properties of V1 neurons, but these are not associated with significant electrophysiologic changes or with cognitive decline.

--- ABSTRACT ---

PMID:24323499 DOI:10.1093/cercor/bht336

2015 Cerebral cortex (New York, N.Y. : 1991)

* Age-related changes to layer 3 pyramidal cells in the rhesus monkey visual cortex.

- The effects of normal aging on morphologic and electrophysiologic properties of layer 3 pyramidal neurons in rhesus monkey primary visual cortex (V1) were assessed with whole-cell, patch-clamp recordings in in vitro slices. In another cohort of monkeys, the ultrastructure of synapses in the layers 2-3 neuropil of V1 was assessed using electron microscopy. Distal apical dendritic branching complexity was reduced in aged neurons, as was the total spine density, due to specific loss of mushroom spines from the apical tree and of thin spines from the basal tree. There was also an age-related decrease in the numerical density of symmetric and asymmetric synapses. In contrast to these structural changes, intrinsic membrane, action potential (AP), and excitatory and inhibitory synaptic current properties were the same in aged and young neurons. Computational modeling using morphologic reconstructions predicts that reduced dendritic complexity leads to lower attenuation of voltage outward from the soma (e.g., backpropagating APs) in aged neurons. Importantly, none of the variables that changed with age differed in neurons from cognitively impaired versus unimpaired aged monkeys. In summary, there are age-related alterations to the structural properties of V1 neurons, but these are not associated with significant electrophysiologic changes or with cognitive decline.

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(1)247 in	(8)8 that	(15)3 have	(22)2 for
(2)31 of	(9)7 during	(16)3 over	(23)2 induced
(3)26 null	(10)6 may	(17)3 the	(24)2 or
(4)26 were	(11)5 at	(18)3 was	(25)2 related
(5)15 to	(12)4 on	(19)2 accompany	(26)2 seen
(6)13 and	(13)3 as	(20)2 can	(27)2 such
(7)8 are	(14)3 by	(21)2 could	(28)2 which

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--- WordNet output for changes --- Overview of noun change The noun change has 10 senses (first 7 from tagged texts) 1. (46) change, alteration, modification -- (an event that occurs when something passes from one state or phase to another; "the change was intended to increase sales"; "this storm is certainly a change for the worse"; "the neighborhood had undergone few modifications since his last visit years ago") 2. (45) change -- (a relational difference between states; especially between states before and after some event; "he attributed the change to their marriage") 3. (17) change -- (the action of changing something; "the change of government had no impact on the economy"; "his change on abortion cost him the election") 4. (13) change -- (the result of alteration or modification; "there were marked changes in the lining of the lungs"; "there had been no change in the mountains") 5. (2) change -- (the balance of money received when the amount you tender is greater than the amount due; "I paid with a twenty and pocketed the change") 6. (1) change -- (a thing that is different; "he inspected several changes before selecting one") 7. (1) change -- (a different or fresh set of clothes; "she brought a change in her overnight bag") 8. change -- (coins of small denomination regarded collectively; "he had a pocketful of change") 9. change -- (money received in return for its equivalent in a larger denomination or a different currency; "he got change for a twenty and used it to pay the taxi driver") 10. variety, change -- (a difference that is usually pleasant; "he goes to France for variety"; "it is a refreshing change to meet a woman mechanic") Overview of verb change The verb change has 10 senses (first 8 from tagged texts) 1. (57) change, alter, modify -- (cause to change; make different; cause a transformation; "The advent of the automobile may have altered the growth pattern of the city"; "The discussion has changed my thinking about the issue") 2. (54) change -- (undergo a change; become different in essence; losing one's or its original nature; "She changed completely as she grew older"; "The weather changed last night") 3. (13) change, alter, vary -- (become different in some particular way, without permanently losing one's or its former characteristics or essence; "her mood changes in accordance with the weather"; "The supermarket's selection of vegetables varies according to the season") 4. (7) switch, shift, change -- (lay aside, abandon, or leave for another; "switch to a different brand of beer"; "She switched psychiatrists"; "The car changed lanes") 5. (6) change -- (change clothes; put on different clothes; "Change before you go to the opera") 6. (5) change, exchange, commute, convert -- (exchange or replace with another, usually of the same kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert centimeters into inches"; "convert holdings into shares") 7. (3) exchange, change, interchange -- (give to, and receive from, one another; "Would you change places with me?"; "We have been exchanging letters for a year") 8. (3) transfer, change -- (change from one vehicle or transportation line to another; "She changed in Chicago on her way to the East coast") 9. deepen, change -- (become deeper in tone; "His voice began to change when he was 12 years old"; "Her voice deepened when she whispered the password") 10. change -- (remove or replace the coverings of; "Father had to learn how to change the baby"; "After each guest we changed the bed linens") --- WordNet end ---