* Protective role of L-carnitine and vitamin E on the testis of atherosclerotic rats.
- Atherosclerosis is a condition caused by lipid build-up and inflammation in the arteries, so hyperlipidemia is the major reason for atherosclerosis. Testis was found to be negatively affected by hyperlipidemia which leads to its impaired functions. Vitamin E and l-carnitine have well-known lipid-lowering and antioxidative activities. Triton WR 1339 is a non-ionic detergent, which induces severe hyperlipidemia by inhibition of lipoprotein lipase. The present study evaluates the protective role of vitamin E and l-carnitine on the testis in atherosclerosis and detects the most effective choice for protection against atherosclerosis; vitamin E, l-carnitine or a combination of both. A total of 80 albino male rats were divided into eight groups (10 rats for each group): control (G1), triton (G2), l-carnitine (G3), triton + l-carnitine (G4), vitamin E (G5), triton + vitamin E (G6), l-carnitine + vitamin E (G7) and triton + l-carnitine + vitamin E (G8). Data showed a significant increase in the levels of total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), 17 beta hydroxysteroid dehydrogenase (17 β HSD), testicular catalase and malondialdehyde (MDA) in G2 when compared with G1, whereas high-density lipoprotein cholesterol (HDL-C), serum testosterone, testicular 17 ketosteroid reductase (17 KSR), total thiol and glutathione-S-transferase (GST) data showed a significant decrease in G2 when compared with G1. Treatment with l-carnitine or/and vitamin E helps in improving the adverse effect of triton; also the histological changes confirm this finding. So the present study recommends all people to include l-carnitine and vitamin E in their diet to be protected against atherosclerosis.
Overview of noun change
The noun change has 10 senses (first 7 from tagged texts)
1. (46) change, alteration, modification -- (an event that occurs when something passes from one
state or phase to another; "the change was intended to increase sales"; "this storm is certainly a
change for the worse"; "the neighborhood had undergone few modifications since his last visit years
ago")
2. (45) change -- (a relational difference between states; especially between states before and
after some event; "he attributed the change to their marriage")
3. (17) change -- (the action of changing something; "the change of government had no impact on the
economy"; "his change on abortion cost him the election")
4. (13) change -- (the result of alteration or modification; "there were marked changes in the
lining of the lungs"; "there had been no change in the mountains")
5. (2) change -- (the balance of money received when the amount you tender is greater than the
amount due; "I paid with a twenty and pocketed the change")
6. (1) change -- (a thing that is different; "he inspected several changes before selecting one")
7. (1) change -- (a different or fresh set of clothes; "she brought a change in her overnight bag")
8. change -- (coins of small denomination regarded collectively; "he had a pocketful of change")
9. change -- (money received in return for its equivalent in a larger denomination or a different
currency; "he got change for a twenty and used it to pay the taxi driver")
10. variety, change -- (a difference that is usually pleasant; "he goes to France for variety"; "it
is a refreshing change to meet a woman mechanic")
Overview of verb change
The verb change has 10 senses (first 8 from tagged texts)
1. (57) change, alter, modify -- (cause to change; make different; cause a transformation; "The
advent of the automobile may have altered the growth pattern of the city"; "The discussion has
changed my thinking about the issue")
2. (54) change -- (undergo a change; become different in essence; losing one's or its original
nature; "She changed completely as she grew older"; "The weather changed last night")
3. (13) change, alter, vary -- (become different in some particular way, without permanently losing
one's or its former characteristics or essence; "her mood changes in accordance with the weather";
"The supermarket's selection of vegetables varies according to the season")
4. (7) switch, shift, change -- (lay aside, abandon, or leave for another; "switch to a different
brand of beer"; "She switched psychiatrists"; "The car changed lanes")
5. (6) change -- (change clothes; put on different clothes; "Change before you go to the opera")
6. (5) change, exchange, commute, convert -- (exchange or replace with another, usually of the same
kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert
centimeters into inches"; "convert holdings into shares")
7. (3) exchange, change, interchange -- (give to, and receive from, one another; "Would you change
places with me?"; "We have been exchanging letters for a year")
8. (3) transfer, change -- (change from one vehicle or transportation line to another; "She changed
in Chicago on her way to the East coast")
9. deepen, change -- (become deeper in tone; "His voice began to change when he was 12 years old";
"Her voice deepened when she whispered the password")
10. change -- (remove or replace the coverings of; "Father had to learn how to change the baby";
"After each guest we changed the bed linens")
--- WordNet end ---