* Effect of sugammadex on rocuronium induced changes in pancreatic mast cells.
- Mast cells play a vital role in hypersensitivity reactions. Rocuronium is known to cause mast cell mobilization, hypersensitivity, and pancreatitis. The aim of this study was to investigate the effects of sugammadex on pancreatic changes due to rocuronium. A total of 42 Sprague-Dawley male rats were divided into six equal groups to receive either rocuronium 1 mg/kg intravenously (i.v., R group), rocuronium 1 mg/kg + sugammadex 16 mg/kg i.v. (RS16 group), rocuronium 1 mg/kg + sugammadex 96 mg/kg i.v. (RS96 group), sugammadex 16 mg/kg (S16), sugammadex 96 mg/kg i.v. (S96 group), or 0.9% sodium chloride (control group). Sugammadex was administered 5s later following rocuronium. In R group, mast count was higher, and the distribution rate of granules and nuclear changes were different compared with other groups. Distribution rate of granules in groups S16 and S96 were similar to the control group and lower compared with other groups. The amount of mast cells and granule density in groups RS16 and RS96 was lower compared with R group. The amount of mast cells in groups RS16 and RS96 was significantly lower compared with other treatment groups. These results suggest that sugammadex may have an inhibitory effect on mobilization and morphological changes in pancreatic mast cells induced by administration of rocuronium and sugammadex in rats.
Overview of noun change
The noun change has 10 senses (first 7 from tagged texts)
1. (46) change, alteration, modification -- (an event that occurs when something passes from one
state or phase to another; "the change was intended to increase sales"; "this storm is certainly a
change for the worse"; "the neighborhood had undergone few modifications since his last visit years
ago")
2. (45) change -- (a relational difference between states; especially between states before and
after some event; "he attributed the change to their marriage")
3. (17) change -- (the action of changing something; "the change of government had no impact on the
economy"; "his change on abortion cost him the election")
4. (13) change -- (the result of alteration or modification; "there were marked changes in the
lining of the lungs"; "there had been no change in the mountains")
5. (2) change -- (the balance of money received when the amount you tender is greater than the
amount due; "I paid with a twenty and pocketed the change")
6. (1) change -- (a thing that is different; "he inspected several changes before selecting one")
7. (1) change -- (a different or fresh set of clothes; "she brought a change in her overnight bag")
8. change -- (coins of small denomination regarded collectively; "he had a pocketful of change")
9. change -- (money received in return for its equivalent in a larger denomination or a different
currency; "he got change for a twenty and used it to pay the taxi driver")
10. variety, change -- (a difference that is usually pleasant; "he goes to France for variety"; "it
is a refreshing change to meet a woman mechanic")
Overview of verb change
The verb change has 10 senses (first 8 from tagged texts)
1. (57) change, alter, modify -- (cause to change; make different; cause a transformation; "The
advent of the automobile may have altered the growth pattern of the city"; "The discussion has
changed my thinking about the issue")
2. (54) change -- (undergo a change; become different in essence; losing one's or its original
nature; "She changed completely as she grew older"; "The weather changed last night")
3. (13) change, alter, vary -- (become different in some particular way, without permanently losing
one's or its former characteristics or essence; "her mood changes in accordance with the weather";
"The supermarket's selection of vegetables varies according to the season")
4. (7) switch, shift, change -- (lay aside, abandon, or leave for another; "switch to a different
brand of beer"; "She switched psychiatrists"; "The car changed lanes")
5. (6) change -- (change clothes; put on different clothes; "Change before you go to the opera")
6. (5) change, exchange, commute, convert -- (exchange or replace with another, usually of the same
kind or category; "Could you convert my dollars into pounds?"; "He changed his name"; "convert
centimeters into inches"; "convert holdings into shares")
7. (3) exchange, change, interchange -- (give to, and receive from, one another; "Would you change
places with me?"; "We have been exchanging letters for a year")
8. (3) transfer, change -- (change from one vehicle or transportation line to another; "She changed
in Chicago on her way to the East coast")
9. deepen, change -- (become deeper in tone; "His voice began to change when he was 12 years old";
"Her voice deepened when she whispered the password")
10. change -- (remove or replace the coverings of; "Father had to learn how to change the baby";
"After each guest we changed the bed linens")
--- WordNet end ---